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Osteopontin

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Definition: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.      Other names Sialoprotein I, Bone; Sialoprotein 1, Bone; Uropontin; Sialoprotein 1; Secreted Phosphoprotein 1; Bone Sialoprotein I; Bone Sialoprotein 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ASK8007 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized Osteopontin/antagonists & inhibitors. Ann Rheum Dis. 2012 Feb;71(2):180-5
Spp1 protein, rat  0   *Osteopontin.
Spp1 protein, mouse  0   *Osteopontin.
SPP1 protein, human  0   *Osteopontin.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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