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Matrix Metalloproteinase 12

More information in Books or onNLM PubMed
Definition: A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.      Other names Metalloproteinase, MMP12; Metalloproteinase, MMP-12; Metalloproteinase 12, Matrix; Metalloelastase, Macrophage-Specific; Metalloelastase, Macrophage; Macrophage Specific Metalloelastase; MMP 12 Metalloproteinase; Elastase, Metalloproteinase; Metalloproteinase Elastase; Macrophage-Specific Metalloelastase; Macrophage Metalloelastase; MMP12 Metalloproteinase; MMP-12 Metalloproteinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-methyl-2-(4-(3-p-tolyl(1,2,4)oxadiazol-5-yl)benzenesulfonylamino)butyric acid  0   *Oxadiazoles *Sulfonamides Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. Endocr J 2011;58(2):101-7
RXP470.1 peptide  0   *Peptides Matrix Metalloproteinase 12/antagonists & inhibitors. Arterioscler Thromb Vasc Biol 2011 mar;31(3):528-35
2-(8-(methoxycarbonylamino)dibenzo(b,d)furan-3-sulfonamido)-3-methylbutanoic acid  0   *Benzofurans *Sulfonamides Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1799-802
(diethyl((methylsulfinyl)methyl)phosphonate)(dimethylmalonato)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
dichloro(diethyl((methylsulfinyl)methyl)phosphonate)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
MMP12 protein, human  EC 3.4.24.65   *Matrix Metalloproteinase 12.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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