Matrix Metalloproteinase 13 (definition)

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Matrix Metalloproteinase 13

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Definition: A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is synthesized as an inactive precursor that is activated by the proteolytic cleavage of its N-terminal propeptide.

Other names Metalloproteinase-13, Matrix; Metalloproteinase, MMP13; Metalloproteinase, MMP-13; Metalloproteinase 13, Matrix; MMP 13 Metalloproteinase; Matrix Metalloproteinase-13; MMP13 Metalloproteinase; MMP-13 Metalloproteinase; Collagenase-3; Collagenase 3

Substance	CAS Registry & name	Categories	Source
4-methyl-1-((5-((3-oxo-3,4-dihydro-2H-benzo(1,4)oxazin-6-ylmethyl)carbamoyl)pyrazolo(1,5-a)pyrimidine-7-carbonyl)amino)indan-5-carboxylic acid	0	Indans Benzoxazines Matrix Metalloproteinase 13/antagonists & inhibitors.	J Med Chem. 2012 Jan 26;55(2):709-16.
PF152 compound	0	Pyrimidines Tetrazoles Matrix Metalloproteinase 13/antagonists & inhibitors.	Arthritis Rheum. 2010 Oct;62(10):3006-15
2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid	0	Sulfonamides Tryptophan/analogs & derivatives Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 13/antagonists & inhibitors Matrix Metalloproteinase 14/antagonists & inhibitors.	Bioorg Med Chem 2009 Jun 1;17(11):3857-65
4-(carboxy-(5-(4'-ethoxyphenyl)thiophene-2-sulfonylamino)methyl)piperidine-1-carboxylic acid isopropyl ester	0	Piperidines Sulfonamides Matrix Metalloproteinase 13/antagonists & inhibitors.	J Med Chem 2009 Jun 11;52(11):3523-38
4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide	0	Hydroxamic Acids Sulfonamides Matrix Metalloproteinase 13/antagonists & inhibitors.	Drug Metab Dispos 2008 Sep;36(9):1869-83
Mmp13 protein, rat	EC 3.4.24.-	*Matrix Metalloproteinase 13.
Mmp13 protein, mouse	EC 3.4.24.-	*Matrix Metalloproteinase 13.
MMP13 protein, human	EC 3.4.24.-	*Matrix Metalloproteinase 13.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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