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Matrix Metalloproteinase 14

More information in Books or onNLM PubMed
Definition: A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.      Other names Metalloproteinase, MT1-Matrix; Metalloproteinase, MMP14; Metalloproteinase, MMP-14; Metalloproteinase 14, Matrix; Membrane Type Matrix Metalloproteinase 1; Membrane Type 1 Matrix Metalloproteinase; MT1 Matrix Metalloproteinase; MMP X1 Protein; MMP 14 Metalloproteinase; Membrane-Type Matrix Metalloproteinase 1; Membrane-Type 1 Matrix Metalloproteinase; MT1-Matrix Metalloproteinase; MT1-MMP; MT-MMP-1; MMP14 Metalloproteinase; MMP-X1 Protein; MMP-14 Metalloproteinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid  0   *Sulfonamides Tryptophan/*analogs & derivatives Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 13/antagonists & inhibitors Matrix Metalloproteinase 14/antagonists & inhibitors. Bioorg Med Chem 2009 Jun 1;17(11):3857-65
Mmp14 protein, mouse  0   *Matrix Metalloproteinase 14.
MMP14 protein, human  EC 3.4.24.80   *Matrix Metalloproteinase 14.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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