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Janus Kinase 2

More information in Books or onNLM PubMed
Definition: A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.      Other names JAK 2 Protein Tyrosine Kinase; JAK2 Protein Tyrosine Kinase; JAK-2 Protein Tyrosine Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo(4,5-d)pyrrolo(2,3b)pyridine-7-carboxamide  0   *Heterocyclic Compounds, 3-Ring Janus Kinase 2/antagonists & inhibitors. Leukemia. 2012 Feb;26(2):280-8.
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene  0   *Heterocyclic Compounds with 4 or More Rings Cyclin-Dependent Kinases/antagonists & inhibitors Janus Kinase 2/antagonists & inhibitors. J Med Chem. 2012 Jan 12;55(1):169-96.
7-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide  0   *Carbolines *Pyrimidines Janus Kinase 2/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7334-49.
CEP 33779  0   *Pyridines *Triazoles Janus Kinase 2/antagonists & inhibitors. J Immunol 2011 Oct 1;187(7):3840-53
preGc1f1fMAF protein, human  0   *Protein Precursors *Macrophage-Activating Factors Janus Kinase 2/antagonists & inhibitors. Anticancer Res 2011 Jul;31(7):2489-92
11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene  0   *Bridged Compounds *Pyrimidines fms-Like Tyrosine Kinase 3/antagonists & inhibitors Janus Kinase 2/antagonists & inhibitors. J Med Chem 2011 Jul 14;54(13):4638-58
AZD 1480  0   *Pyrazoles *Pyrimidines Janus Kinase 2/antagonists & inhibitors. Cancer Cell. 2009 Dec 8;16(6):487-97
5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile  0   *Aminopyridines *Pyrazoles Janus Kinase 2/antagonists & inhibitors. J Biol Chem 2008 Nov 21;283(47):32334-43
Jak2 protein, rat  EC 2.7.1.112   *Janus Kinase 2.
Jak2 protein, mouse  EC 2.7.1.112   *Janus Kinase 2.
JAK2 protein, human  EC 2.7.1.112   *Janus Kinase 2.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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