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Receptors, Thrombopoietin

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Definition: Cell surface receptors that are specific for THROMBOPOIETIN. They signal through interaction with JANUS KINASES such as JANUS KINASE 2.      Other names Receptor, Thrombopoietin; Receptor, MPL Ligand; Ligand Receptor, MPL; Thrombopoietin Receptors; Thrombopoietin Receptor; MPL Ligand Receptor; CD110 Antigens; Antigens, CD110
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALXN4100TPO  0   *Antibodies, Monoclonal *Thrombopoietin Receptors, Thrombopoietin/agonists. Radiat Res. 2011 Jun;175(6):746-58
1-(3-chloro-5-((4-(4-chloro-2-thienyl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-2-pyridyl)piperidine-4-carboxylic acid  0   *Thiazoles *Thiophenes Receptors, Thrombopoietin/agonists. Exp Hematol 2008 Oct;36(10):1337-42
thrombopoietin mimetic peptide  0   *Peptides Receptors, Thrombopoietin/agonists. Science 1997 Jun 13;276(5319):1696-9
romiplostim  0   *Receptors, Fc *Recombinant Fusion Proteins *Thrombopoietin Receptors, Thrombopoietin/agonists. Cytokine 2004 Jan 21;25(2):52-60NPLATE
Mpl protein, mouse  0   *Receptors, Thrombopoietin. EMBO J 1993 Jul;12(7):2645-53
MPL protein, human  143641-95-6   *Receptors, Thrombopoietin Thrombopoietin. Embo J 1993 Jul;12(7):2645-53; Proc Natl Acad Sci USA 1992 Jun 15;89(12):5640-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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