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Naphthalimides

More information in Books or onNLM PubMed
Definition: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-thiophenyl-N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide  0   *Thiophenes *Naphthalimides. J Photochem Photobiol B. 2011 Oct 5;105(1):75-80
amino acetamide-NDI-lysyl-beta-alanyl-beta-alanyl-beta-alanyl-NDI-lysyl-adipamide-lysyl-NDI-beta-alanyl-beta-alanyl-beta-alanyl-lysyl-NDI-amino acetamide  0   *Peptides *Naphthalimides. Nat Chem. 2011 Nov;3(11):875-81.
4-butoxyethoxy-N-octadecyl-1,8-naphthalimide  0   *Naphthalimides. Bioorg Med Chem Lett 2011 Jun 15;21(12):3798-804
6-methoxyethylaminonumonafide  0   *Naphthalimides. Neoplasia 2011 May;13(5):453-60
6-aminonumonafide  0   *Naphthalimides. Neoplasia 2011 May;13(5):453-60
NPC 16  0   *Polyamines *Naphthalimides. Apoptosis 2011 Jan;16(1):27-34
6-(dodecylamino)-2-(3-(4-methylpiperazin-1-yl)propyl)-1H-benzo-(de)isoquinoline-1,3(2H)-dione  0   *Naphthalimides. Leuk Res. 2011 May;35(5):646-56
bisnaphthalimidopropyldiaaminooctane  0   *Naphthalimides. Bioorg Med Chem 2007 Jan 1;15(1):541-5
N-(2-(dimethylamino)ethyl)-2-aminothiazonaphthalimide  0   *Benzothiazoles *Naphthalimides. Mol Cancer Res 2010 Dec;8912):1619-32
2-(6-chloro-1,3-dioxo-1H-benzo(f)isoindol-2(3H)-yl)acetic acid  0   *Naphthalimides. Org Biomol Chem 2010 Mar 21;8(6):1296-300
N-propyl-4-(2-(1,4,7,10-tetrathia-13-azacyclopentadecane)ethylamino)-1,8-naphthalimide  0   *Naphthalimides. Dalton Trans 2010 Feb 7;39(5):1316-20
N-hydroxyarene-1,8-naphthalimide  0   *Naphthalimides. J Fluoresc. 2009 Jul;19(4):681-91
4,5-diamino-1,8-naphthalimide  0   *Naphthalimides. Org Biomol Chem. 2009 Apr 7;7(7):1299-303
4-N,N-dimethylamino-1,8-naphthalimide  0   *Naphthalimides. J Am Chem Soc. 2008 Oct 15;130(41):13630-8
N-(3-bromopropyl)-4-piperidino-1,8-naphthalimide  0   *Naphthalimides. Acta Crystallogr C 2008 Jul;64(Pt 7):o388-91
N-(2-bromoethyl)-4-piperidino-1,8-naphthalimide  0   *Naphthalimides. Acta Crystallogr C 2008 Jul;64(Pt 7):o388-91
UNBS 5162  0   *Naphthalimides Urea/*analogs & derivatives. Neoplasia 2008 Jun;10(6):573-86
N-epoxymethyl-1,8-naphthalimide  0   *Naphthalimides. Int J Pharm 2008 May 22;356(1-2):130-6
N-hydroxynaphthalimide triflate  0   *Naphthalimides Hydrocarbons, Fluorinated. Phys Chem Chem Phys. 2008 Mar 7;10(9):1257-62
RTA 502  0   *Naphthalimides *Acridones. J Med Chem 2007 Nov 15;50(23):5557-60
2-(2-dimethylamino)-6-thia-2-azabenzo(def)chrysene-1,3-dione  0   *Thiophenes *Naphthalimides DNA Topoisomerases, Type II/antagonists & inhibitors. Mol Cancer Ther 2007 Feb;6(2):484-95
xanafide  0   *Naphthalimides. Br J Cancer 2007 Jul 2;97(1):58-64
bis(2-(1,8-naphthalimid-2-yl)ethyl)amine  0   *Naphthalimides. Spectrochim Acta A Mol Biomol Spectrosc 2007 May;67(1):87-91
2-methyl-1,8-epoxynaphthalimide  0   *Epoxy Compounds *Naphthalimides. Cell Cycle 2007 Jul;6(13):1621-30
2,6-bis(4'-piperazino-N'-butyl-1',8'-naphthalimide)dimethylpyridine  0   *Piperazines *Quinolones *Naphthalimides. Chem Res Toxicol 2005 Dec;18(12):1814-20
2,6-bis(4'-piperazino-N'-hydroxyethoxyethylene-1',8'-naphthalimide)dimethylpyridine  0   *Piperazines *Quinolones *Naphthalimides. Chem Res Toxicol 2005 Dec;18(12):1814-20
4-methoxy-N-methyl-1,8-naphthalimide  0   *Naphthalimides. Spectrochim Acta A Mol Biomol Spectrosc 2006 Jan;63(1):220-6
virstatin  0   *Butyric Acids *Naphthalimides. Science 2005 Oct 28;310(5748):670-4
N-trifluoromethylsulfonyloxy-1,8-naphthalimide  0   *Mesylates *Naphthalimides. Photochem Photobiol Sci 2005 Jan;4(1):83-8
6-N,N-dimethylamino-2,3-naphthalimide  0   *Naphthalimides. J Am Chem Soc. 2005 Feb 2;127(4):1300-6
4-methylamino-1,8-naphthalimide  0   *Naphthalimides. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2363-6
STO 609  0   *Benzimidazoles *Naphthalimides. J Biol Chem 2002 May 3;277(18):15813-8
N-allyl-4-(N-2'-hydroxyethyl)amino-1,8-naphthalimide  0   *Allyl Compounds *Naphthalimides. Analyst 2002 Apr;127(4):512-7
6-bromo-2-(2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)-1H-benz-(de)isoquinoline-1,3-dione  0   *Nitrosourea Compounds *Naphthalimides. Acta Pol Pharm 2001 Sep-Oct;58(5):351-8
6-chloro-2-(2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)-1H-benz-(de)isoquinoline-1,3-dione  0   *Nitrosourea Compounds *Naphthalimides. Acta Pol Pharm 2001 Sep-Oct;58(5):351-8
azonafide  0   *Naphthalimides. J Med Chem 1995 Mar 17;38(6):983-93
3-bromo-4-(hexylamino)-N-hexyl-1,8-naphthalimide  0   *Naphthalimides 1-Naphthylamine/*analogs & derivatives. Antiviral Res 1994 Oct;25(2):133-46
RS 56532  138752-34-8 1H-Benz0(de)isoquinoline-1,3(2H)-dione, 6-amino-2-(1-azabicyclo(2.2.2)oct-3-yl)-5-chloro-, monohydrochloride, (S)  *Quinuclidines *Naphthalimides. Neuropharmacology 1994 Mar-Apr;33(3-4):515-26
4-amino-1,8-naphthalimide  1742-95-6   *Quinolones *Naphthalimides 1-Naphthylamine/*analogs & derivatives Poly(ADP-ribose) Polymerases. Biochem Biophys Res Commun 1994 Mar 30;199(3):1270-7
1,14-bis-(N-hexyl-3'-bromo-1,8'-naphthalimide-4'-yl)-1,4,11,14-tetraazatetradecane-5,10-dione  149849-59-2   *Naphthalimides 1-Naphthylamine/*analogs & derivatives HIV-1. AIDS Res Hum Retroviruses 1993 Sep;9(9):891-6
amonafide  69408-81-7 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)  *Naphthalimides.
Pharma Action Antineoplastic Agents ; Antiviral Agents ; Enzyme Inhibitors ; Intercalating Agents 		Arch Virol 1982;74(2-3):157
mitonafide  54824-17-8 2-(2-(dimethylamino)ethyl)-5-nitro-1H-benz(de)isoquinoline-1,3(2H)-dione  *Naphthalimides.
Pharma Action Antineoplastic Agents ; Antiviral Agents ; Intercalating Agents 		Arch Framacol Toxicol 5(1):17;1979; Cancer Chemother Pharmacol 1980;4(1):61; Chemotherapy 25(2):83;1979; Nucleic Acids Res1979;7(1):217

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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