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Chymases

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Definition: A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.      Other names Chymotrypsin Like Proteases; Chymotrypsin Like Protease; Chymase 1; Chymotrypsin-Like Proteases; Chymotrypsin-Like Protease; Chymase-1; Chymase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RO 5066852  0   *Indoleacetic Acids *Naphthalenes Chymases/antagonists & inhibitors. Cardiovasc Res 2011 Jan 1;89(1):244-52
4-(1-(naphthylmethyl)benzimidazol-2-ylthio)butanoic acid  0   *Benzimidazoles *Butyrates Chymases/antagonists & inhibitors. J Cardiovasc Pharmacol 2003 Jan;41 Suppl 1:S11-8
4-(1-(4-methylbenzo(b)thiophen-3-ylmethyl)-1H-benzimidazol-2-ylsulfanyl)butyric acid  0   *Butyric Acids *Thiophenes Chymases/antagonists & inhibitors. J Pharmacol Sci 2009 Sep;111(1):82-90
TY 51469  0   *Sulfonamides *Thiophenes Chymases/antagonists & inhibitors. Exp Biol Med (Maywood) 2007 Oct;232(9):1213-21
SUN 13350  0   *Azepines Chymases/antagonists & inhibitors. J Invest Dermatol 2007 Apr;127(4):971-3
Mcpt1 protein, rat  EC 3.4.21.39   *Chymases.
Mcpt1 protein, mouse  EC 3.4.21.39   *Chymases.
Cma2 protein, mouse  EC 3.4.21.39   *Chymases.
Cma1 protein, rat  EC 3.4.21.39   *Chymases.
Cma1 protein, mouse  EC 3.4.21.-   *Chymases.
CMA1 protein, human  EC 3.4.21.39   *Chymases.
chymase 2  EC 3.4.21.-   *Chymases Mast Cells. J Immunol 1993 Sep 15;151(6):3206-14

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