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Receptors, Ghrelin

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Definition: Transmembrane proteins that recognize and bind GHRELIN, a potent stimulator of GROWTH HORMONE secretion and food intake in mammals. Ghrelin receptors are found in the pituitary and HYPOTHALAMUS. They belong to the family of G-PROTEIN-COUPLED RECEPTORS.      Other names Receptor, Ghrelin; Ghrelin Receptors; Receptor, Growth Hormone Secretagogue 1A; Growth Hormone Secretogogue Receptor 1B; Growth Hormone Secretagogue Receptor Type 1B; Growth Hormone Secretagogue Receptor Type 1A; Growth Hormone Secretagogue Receptor Type 1; GHS R Type 1A; Ghrelin Receptor; GHSR Protein; GHS-R1B; GHS-R1A; GHS-R Type 1A; GHS Receptor Type 1; Growth Hormone Secretagogue Receptors; Growth Hormone Secretagogue Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ghsr1a protein, rat  0   *Receptors, Ghrelin. Mol Pharmacol. 2007 Aug;72(2):380-6.
N'-(3,5-bis(trifluoromethyl)phenyl)-2-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-2-(3-pyridinyl)ethanohydrazide  0   *Hydrazines *Azabicyclo Compounds Receptors, Ghrelin/antagonists & inhibitors. Eur J Pharmacol 2011 Jan 10;650(1):178-83
5-(2-methylalanyl)-O-((2,4difluorophenyl)methyl)-seryl-3-oxo-3a-(2 pyridinylmethyl)-2-(2,2,2 trifluoroethyl)-3,3a,4,5,6,7-hexahydro-2H pyrazolo(4,3-c)pyridine  0   *Pyridines Serine/*analogs & derivatives Receptors, Ghrelin. Psychopharmacology (Berl) 2009 Oct;206(3):415-27
N-(5-(3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl)-4-(5-methyl-2-furanyl) benzenesulfonamide  0   *Piperazines *Sulfonamides Receptors, Ghrelin. Psychopharmacology (Berl) 2009 Oct;206(3):415-27
N-(1-(5-(2-(1H-indol-3-yl)ethyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)pyrazine-2-carboxamide  0   *Pyrazines *Triazoles Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2008 Feb 14;51(3):689-93
N-(1-(4-(2,4-dimethoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)picolinamide  0   *Picolines *Triazoles Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2008 Feb 14;51(3):689-93
YIL 870  0   *Piperidines *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. Endocrinology 2007 Nov;148(11):5175-85
YIL 781  0   *Piperidines *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. Endocrinology 2007 Nov;148(11):5175-85
6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one  0   *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5202-16
6-(4-fluorophenyl)-2-isopropyl-3-((1-isopropylpiperidin-3-yl)methyl)quinazolin-4(3H)-one  0   *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5202-16

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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