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p21-Activated Kinases

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Definition: A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.      Other names PAK65; p21-Activated Kinase, beta; p21 Activated Kinases; p21 Activated Kinase 3; p21 Activated Kinase 2; p21 Activated Kinase 1; gamma PAK; beta p21 Activated Kinase; alpha p21 Activated Kinase; Serine Threonine Protein Kinase PAK 3; Serine Threonine Protein Kinase PAK 1; PAK 2 Kinase; PAK 1 Kinase; Oligophrenin 3; Kinases, p21-Activated; Kinases, PAK; p65PAK Protein; p65(PAK); p21-Activated Kinase 3; p21-Activated Kinase 2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PAK4 protein, Xenopus  EC 2.7.11.1   *Xenopus Proteins *p21-Activated Kinases. J Cell Biol 2010 Sep 6;190(5):807-22
PF 3758309  0   *Pyrazoles *Pyrroles p21-Activated Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2010 May 18;107(20):9446-51
Pak6 protein, mouse  EC 2.7.11.1   *p21-Activated Kinases. Dev Biol 2008 Oct 1;322(1):95-108
shk2 protein, S pombe  EC 2.7.11.1   *Schizosaccharomyces pombe Proteins *p21-Activated Kinases.
Pak3 protein, rat  0   *p21-Activated Kinases.
Pak3 protein, mouse  EC 2.7.11.1   *p21-Activated Kinases.
PAK3 protein, human  EC 2.7.11.1   *p21-Activated Kinases.
Pak2 protein, rat  EC 2.7.11.1   *p21-Activated Kinases.
Pak2 protein, mouse  EC 2.7.11.1   *p21-Activated Kinases.
PAK2 protein, human  EC 2.7.11.1   *p21-Activated Kinases.
Pak1 protein, rat  EC 2.7.11.1   *p21-Activated Kinases.
Pak1 protein, mouse  0   *p21-Activated Kinases.
PAK1 protein, human  EC 2.7.11.1   *p21-Activated Kinases.
Pak4 protein, mouse  EC 2.7.11.1   *p21-Activated Kinases.
X-PAK5 protein, Xenopus  EC 2.7.11.1   *Xenopus Proteins *p21-Activated Kinases.
Pak7 protein, mouse  EC 2.7.1.11   *p21-Activated Kinases.
PAK protein, Entamoeba histolytica  0   *p21-Activated Kinases. J Cell Sci 2003 Jan 1;116(Pt 1):61-71
PAK7 protein, human  EC 2.7.1.11   *p21-Activated Kinases. J Cell Biol 2001 Dec 10;155(6);1029-42
PAK6 protein, human  EC 2.7.11.1   *p21-Activated Kinases. J Biol Chem 2001 May 4;276(18):15345-3
PAK4 protein, human  EC 2.7.1.11   *p21-Activated Kinases. EMBO J 1998 Nov 16;17(22):6527-40
pak-1 protein, C elegans  EC 2.7.1.11   *p21-Activated Kinases *Caenorhabditis elegans Proteins. J Biol Chem 1996 Oct 18;271(42):26362-8
Pak protein, Drosophila  EC 2.7.1.-   *Drosophila Proteins *p21-Activated Kinases. Mol Cell Biol 1996 May;16(5):1896-908
pak1 protein, S pombe  EC 2.7.1.37   *Schizosaccharomyces pombe Proteins *p21-Activated Kinases. Proc Natl Acad Sci U S A 1995 Jun 20;92(13):6180-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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