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Phospholipases A2

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Definition: Phospholipases that hydrolyzes the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.  general; prefer specifics   
Examples 1-Alkyl-2-acetylglycerophosphocholine Esterase; Phospholipases A2, Calcium-Independent; Phospholipases A2, Cytosolic; Phospholipases A2, Secretory 		Other names Phospholipase A2; Lecithinase A2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PF-5212372  0   *Phenylpropionates *Sulfonamides Phospholipases A2/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65.
Pla2g7 protein, mouse  EC 3.1.1.4   *Phospholipases A2. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):730-44
1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile  0   *Benzofurans Phospholipases A2/antagonists & inhibitors. Basic Clin Pharmacol Toxicol. 2011 Oct;109(4):292-9.
methyl 6-methoxy-2-phenethylquinoline-4-carboxylate  0   *Quinolines Phospholipases A2/antagonists & inhibitors. Bioorg Med Chem 2011 Jun 1;19(11):3361-6
Pla2g7 protein, rat  EC 3.1.1.4   *Phospholipases A2. Biochim Biophys Acta. 2011 Jun;1811(6); 409-17
CMS-9 protein, Naja nigricollis  0   *Cobra Venoms *Phospholipases A2. Toxicon 2010 Jun 15;55(7):1306-16
CDC-10 protein, Crotalus durissus  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):66-74
CDC-9 protein, Crotalus durissus  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):66-74
brazilitoxin III, Bothrops brazili  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Toxicon 2009 Nov;54(6):818-27
brazilitoxin II, Bothrops brazili  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Toxicon 2009 Nov;54(6):818-27
varespladib methyl  0   *Acetates *Indoles Phospholipases A2/antagonists & inhibitors. IDrugs 2009 Sep;12(9):585-92
Lys49-phospholipase A2, Bothrops lternatus  EC 3.1.1.-   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):291-7
MVL-PLA2, Macrovipera lebetina  EC 3.1.1.4   *Viper Venoms *Phospholipases A2. Matrix Biol. 2009 May;28(4):188-93
FKGK2 compound  0   *Ketones Phospholipases A2/antagonists & inhibitors. Brain 2009 May;132(Pt 5):1221-35
AX 115  0   *Amides Phospholipases A2/antagonists & inhibitors. Brain 2009 May;132(Pt 5):1221-35
AX 059  0   *Amides Phospholipases A2/antagonists & inhibitors. Brain 2009 May;132(Pt 5):1221-35
adipose-specific phospholipase A2, rat  EC 3.1.1.4   *Phospholipases A2. J Biol Chem 2008 Sep 12;283(37):25428-36
Cr-IV 1 myotoxin, Calloselasma rhodostoma  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Biologicals 2008 May;36(3):168-76
Otoc1 protein, zebrafish  0   *Extracellular Matrix Proteins *Zebrafish Proteins Calcium-Binding Proteins Phospholipases A2. Dev Neurobiol 2008 Feb 1;68(2):209-22
PLA2G7 protein, human  EC 3.1.1.4   *Phospholipases A2. Arterioscler Thromb Vasc Biol 1996 Apr;16(4):591-9
BnSP-6  EC 3.1.1.-   *Crotalid Venoms *Phospholipases A2. Biochem Biophys Res Commun 2003 Nov 21;311(3):713-20
vaspin protein, Vipera aspis aspis  EC 3.1.1.4   *Reptilian Proteins *Phospholipases A2 Viper Venoms. FEBS Lett 2002 Sep 11;527(1-3):263-8
phospholipin  EC 3.1.1.-   *Phospholipases A2 Scorpion Venoms. FEBS Lett 1999 Nov 5;460(3):447-50
phospholipase A2, group XV  EC 3.1.1.4   *Acyltransferases *Phospholipases A2. Methods Enzymol 2000;311:105-17
plasmalogen-selective phospholipase A2  EC 3.1.1.4   *Phospholipases A2. Methods Mol Biol 1999;109:39-47
acanthoxin  EC 3.1.1.4   *Phospholipases A2 Elapid Venoms. Toxicon 1997 Aug;35(8):1315-25
7-hydroxycoumarinyl ester hydrolase  EC 3.1.1.4   *Phospholipases A2. Anal Biochem 1994 Oct;222(1):110-5
prophospholipase A2  EC 3.1.1.4   *Enzyme Precursors *Phospholipases A2. Biochem Biophys Res Commun 1994 Jan 14;198(1):10-5
Oxyuranus scutellatus toxin 2  EC 3.1.1.4   *Reptilian Proteins *Phospholipases A2 Elapid Venoms. Neurochem Res 1991 Jun;16(6):651-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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