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Protein Tyrosine Phosphatase, Non-Receptor Type 1

More information in Books or onNLM PubMed
Definition: A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.      Other names Protein Tyrosine Phosphatase, Non Receptor Type 1; Protein Tyrosine Phosphatase HA2; Protein-Tyrosine Phosphatase HA2; Protein Tyrosine Phosphatase 1B; PTPase HA2; PTPase 1B
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CCF 06240  0   *Benzofurans *Phenylpropionates Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. Mol Cell Biochem. 2011 Nov;357(1-2):65-72.
(((5-(1,1-dimethylethyl)thiazol-2-yl)methyl)(((4-(4-(4-(1-propylbutyl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)amino)acetic acid  0   *Thiazoles Glycine/*analogs & derivatives Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. Diabetes Obes Metab 2010 Apr;12(4):299-306
ilekudinol A  0   *Triterpenes Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. Phytother Res. 2010 Nov;24(11):1716-9
3-oxo-28-(phthaloyl-4')erythrane  0   Oleanolic Acid/*analogs & derivatives Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. J Nat Prod. 2010 Nov 29;73(11):1743-50
2-(2-carboxybenzoylamino)-4-(3'-chloro-4'-fluorobiphenyl-4-yl)thiophene-3-carboxylic acid ethyl ester  0   *Phthalic Acids *Thiophenes Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. Bioorg Med Chem 2010 Mar 1;18(5):1773-82
Ptpn1 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 1.
Ptpn1 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 1.
PTPN1 protein, human  EC 3.1.3.48   *Protein Tyrosine Phosphatase, Non-Receptor Type 1.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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