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Dual-Specificity Phosphatases

More information in Books or onNLM PubMed
Definition: A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.     
Examples cdc25 Phosphatases; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 2; Dual Specificity Phosphatase 3; Dual Specificity Phosphatase 6 		Other names Phosphatases, Dual-Specificity; Phosphatases, DUSP; Phosphatase, Dual-Specificity; Dual Specificity Phosphatases; Dual Specificity Phosphatase; Dual-Specificity Phosphatase; DUSP Phosphatases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SEX4 protein, Arabidopsis  EC 3.1.3.48   *Arabidopsis Proteins *Dual-Specificity Phosphatases. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15379-84
Dusp5 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases. Brain Res 2008 Nov 6;1239:42-8
2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one  0   *Cyclohexylamines *Indenes Dual-Specificity Phosphatases/antagonists & inhibitors. Nat Chem Biol 2009 Sep;5(9):680-7
CDC14B protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases. Biol Reprod 2009 Apr;80(4):795-803
DUSP4 protein, zebrafish  EC 3.1.3.48   *Zebrafish Proteins *Dual-Specificity Phosphatases. Proc Natl Acad Sci U S A 2008 Aug 26;105(34):12337-42
Dusp7 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases. Dev Dyn 2008 Jan;237(1):163-9
Dusp22 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases.
DUSP8 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases.
Dusp5 protein, rat  EC 3.1.3.48   *Dual-Specificity Phosphatases. FASEB J 2006 Oct;20(12):2127-9
DSP4 protein, Arabidopsis  EC 3.1.3.16   *Arabidopsis Proteins *Dual-Specificity Phosphatases. Proc Natl Acad Sci U S A 2006 Jun 20;103(25):9732-7
Dusp10 protein, mouse  EC 3.1.3.36   *Dual-Specificity Phosphatases. Mol Cell Biol 2005 Oct;25(19):8619-30
VHP-1 protein, C elegans  EC 3.1.3.48   *Caenorhabditis elegans Proteins *Dual-Specificity Phosphatases. EMBO J 2004 Jun 2;23(11):2226-34
DUSP26 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Biochem Biophys Res Commun 2005 May 6;330(2):511-8
Dusp23 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases. Biochem J 2004 Nov 1;383(Pt 3):447-55
Dusp14 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases.
DUSP14 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases.
DUSP13 protein, human  EC 3.1.3.16   *Dual-Specificity Phosphatases.
DUSP23 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Int J Biochem Cell Biol. 2004 Aug;36(8):1542-53
Epm2a protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases.
Epm2a protein, rat  EC 3.1.3.48   *Dual-Specificity Phosphatases.
DUSP4 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases.
dual specificity phosphatase 12  EC 3.1.3.16   *Dual-Specificity Phosphatases.
Dusp9 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases.
IBR5 protein, Arabidopsis  EC 3.1.3.48   *Arabidopsis Proteins *Dual-Specificity Phosphatases. Plant Cell. 2003 Dec;15(12); 2979-91
YVH1 phosphatase, Plasmodium falciparum  EC 3.1.3.48   *Protozoan Proteins *Dual-Specificity Phosphatases. Mol Biochem Parasitol 2004 Feb;133(2):297-310
DsPTP1 protein, Arabidopsis  EC 3.1.3.48   *Arabidopsis Proteins *Dual-Specificity Phosphatases. Plant J 1998 Dec;16(5):581-9
DUSP19 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Int J Biochem Cell Biol 2003 Feb;35(2):226-34
CDC14B protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. J Biol Chem 1997 Nov 21;272(47):29403-6
DUSP18 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Biochim Biophys Acta 2003 Feb 20;1625(3):296-304
DUSP21 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Biochem Biophys Res Commun 2002 Nov 8;298(4):545-51
SDP1 protein, S cerevisiae  EC 3.1.3.16   *Dual-Specificity Phosphatases. FEBS Lett 2002 Sep 11;527(1-3):186-92
DUSP22 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13613-8
DUSP5 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Am J Respir Cell Mol Biol 2001 Oct;25(4):425-33
DUSP16 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 2001 Oct 19;276(42):39002-11
Dusp16 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Mol Cell Biol 2001 Oct;21(20):6999-7009
Dusp13 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases. Biochem J 1999 Dec 15;344 Pt 3:787-95
YVH1 protein, S cerevisiae  EC 3.1.3.48   *Saccharomyces cerevisiae Proteins *Dual-Specificity Phosphatases. J Bacteriol 1999 Sep;181(17):5219-24
DUSP10 protein, human  EC 3.1.3.16   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1999 Jul 9;274(28):19949-56; Oncogene 1999 Nov 25;18(50):6981-8
DUSP11 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. J Biol Chem 1998 Aug 7;273(32):20347-53
DUSP7 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases. Genomics 1997 Jun 15;42(3):524-7
DUSP9 protein, human  EC 3.1.3.-   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1997 Feb 21;272(8):5141-51
Dusp4 protein, rat  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1995 Jun 16;270(24):14587-96
CDKN3 protein, human  EC 3.1.3.48   *Cyclin-Dependent Kinase Inhibitor Proteins *Dual-Specificity Phosphatases. Cell 1993 Nov 19;75(4):791-803; J Neurochem 2004 Jun;89(5):1252-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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