Dual Specificity Phosphatase 1 (definition)

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Dual Specificity Phosphatase 1

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Definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Other names Protein Phosphatase-1, Mitogen-Activated; Phosphatase-1, Mitogen-Activated Protein; Phosphatase-1, MAP; Phosphatase, MKP-1; Phosphatase, MAPK; Phosphatase, CL100; Phosphatase, 3CH134; Mitogen Activated Protein Phosphatase 1; MKP 1 Phosphatase; MAP Phosphatase 1; Mitogen-Activated Protein Phosphatase-1; Map Kinase Phosphatase 1; MKP-1 Phosphatase; MAPK Phosphatase; MAP Phosphatase-1; Externally Regulated Phosphatase (ERP); CL100 Phosphatase; 3CH134 Phosphatase

Substance	CAS Registry & name	Categories	Source
Dmel-MKP protein, Drosophila	EC 3.1.3.48	Drosophila Proteins Dual Specificity Phosphatase 1.
Dusp1 protein, rat	EC 3.1.3.48	*Dual Specificity Phosphatase 1.
Dusp1 protein, mouse	EC 3.1.3.48	*Dual Specificity Phosphatase 1.
DUSP1 protein, human	EC 3.1.3.48	*Dual Specificity Phosphatase 1.
Pmp1 protein, S pombe	EC 3.1.3.-	Schizosaccharomyces pombe Proteins Dual Specificity Phosphatase 1.	EMBO J 1998 Jan 2;17(1):140-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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