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Cyclic Nucleotide Phosphodiesterases, Type 4

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Definition: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.      Other names cAMP Specific Phosphodiesterase 4A5; Phosphodiesterases, PDE4; Phosphodiesterase, PDE4D3; Phosphodiesterase 4A5, cAMP-Specific; cAMP-Specific Phosphodiesterase 4A5; Type 4 Cyclic Nucleotide Phosphodiesterase; Phosphodiesterase-4; Phosphodiesterase IV; Phosphodiesterase 4D; Phosphodiesterase 4C; Phosphodiesterase 4B; Phosphodiesterase 4A; Phosphodiesterase 4; PDE4D3 Phosphodiesterase; PDE4 Phosphodiesterases; Cyclic Nucleotide Phosphodiesterases, Type 4D3; Cyclic Nucleotide Phosphodiesterases, Type 4D; Cyclic Nucleotide Phosphodiesterases, Type 4C; Cyclic Nucleotide Phosphodiesterases, Type 4B; Cyclic Nucleotide Phosphodiesterases, Type 4A5
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GEBR-7b  0   *Imines *Morpholines Phosphodiesterase Inhibitors Cyclic Nucleotide Phosphodiesterases, Type 4. Br J Pharmacol. 2011 Dec;164(8):2054-63.
hesperetin-7,3'-O-dimethylether  0   Hesperidin/*analogs & derivatives Phosphodiesterase Inhibitors Cyclic Nucleotide Phosphodiesterases, Type 4. J Biomed Sci. 2011;18:84.
3-(4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)propanoic acid  0   *Naphthyridines Cyclic Nucleotide Phosphodiesterases, Type 4. Int Immunopharmacol 2011 Jun;11(6):732-9
N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-N-methyl-3-(3-pyridyl)-2-propenamide  0   *Acrylamides *Pyridines Cyclic Nucleotide Phosphodiesterases, Type 4. Chem Exp Nephrol 2011 Feb;15(1):14-24
(2,4-dibromo-3,6-dihydroxyphenyl)acetic acid  0   *Phenylacetates Cyclic Nucleotide Phosphodiesterases, Type 4. Chem Biodivers 2010 Dec;7(12):2880-7
6-((3-((dimethylamino)carbonyl)phenyl)sulfonyl)-8-methyl-4-((3-methyloxyphenyl)amino)-3-quinolinecarboxamide  0   *Aminoquinolines *Sulfones Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Respir Res 2010;11:26
Zl-n-91 compound  0   *Furans *Phenyl Ethers Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Int Immunopharmacol 2010 Feb;10(2):252-8
PDE4C protein, rat  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4. J Lipid Res 2007 May;48(5):1099-107
PDE4B protein, rat  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4. J Neurochem 2002 May;81(4):745-57
PDE4B protein, mouse  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6
4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid  0   *Cyclohexanecarboxylic Acids *Dioxanes Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Int Immunopharmacol 2009 Jan;9(1):55-62
MK 0873  0   *Naphthyridines Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Pulm Pharmacol Ther 2008;21(3):573-7
PDE4D protein, mouse  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4. Cell Signal 2008 Jan;20(1):139-53
KW 4490  0   *Cyclohexanecarboxylic Acids *Dioxanes Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Xenobiotica 2008 May;38(5):511-26
PDE4C protein, human  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4.
PDE4B protein, human  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4.
PDE4A protein, human  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4.
Pde4a protein, mouse  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 4. Biochem J 1995 Sep 15;310(Pt 3):965-74

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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