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Cyclic Nucleotide-Gated Cation Channels

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Definition: Ion channels that are regulated by cyclic GMP or cyclic AMP binding and contain six transmembrane segments and an ion conducting pore that passes monovalent cations. They are expressed in OLFACTORY NERVE cilia and in PHOTORECEPTOR CELLS and some PLANTS. They are blocked by DILTIAZEM.      Other names Hyperpolarization Cyclic Nucleotide Gated Ion Chan; Gated Channel, Cyclic-Nucleotide; Cyclic Nucleotide Gated Ion Channels; Cyclic Nucleotide Gated Channel; Cyclic Nucleotide Gated Cation Channels; Cyclic Nucleotide Gated Cation Channel; Channel, Cyclic-Nucleotide Gated; Channel, Cng Cation; Cation Channel, Cng; Hyperpolarization Cyclic-Nucleotide Gated Ion Chan; Cyclic-Nucleotide Gated Channel; Cyclic Nucleotide-Gated Cation Channel; Cng Cation Channel; Cationic Channel Protein (Rod); CNG Channel (Rod); Cyclic-Nucleotide Gated Ion Channels
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CNGA1 protein, rat  0   *Cyclic Nucleotide-Gated Cation Channels. Pflugers Arch 2011 Aug;462(2):267-79
CNGB3 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels. Hum Mol Genet 2000 Sep 1;9(14):2107-16
Cngb1 protein, mouse  0   *Nerve Tissue Proteins *Cyclic Nucleotide-Gated Cation Channels. Neuron 2008 May 8;58(3):374-86
CNGC10 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclic Nucleotide-Gated Cation Channels. BMC Plant Biol 2007;7:48
Cncg protein, rat  0   *Cyclic Nucleotide-Gated Cation Channels.
CNGA1 protein, human  0   *Cyclic Nucleotide-Gated Cation Channels.
Cnga1 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels.
CNGA2 protein, human  0   *Cyclic Nucleotide-Gated Cation Channels.
Cnga2 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels.
Cnga2 protein, rat  0   *Cyclic Nucleotide-Gated Cation Channels.
CNGA3 protein, human  0   *Cyclic Nucleotide-Gated Cation Channels.
Cnga3 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels.
Cnga4 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels.
CNGB1 protein, human  0   *Cyclic Nucleotide-Gated Cation Channels.
cyclic GMP-dependent channel protein (rod outer segment)  0   *Cyclic Nucleotide-Gated Cation Channels.
ATCNGC4 protein, Arabidopsis  0   *Cyclic Nucleotide-Gated Cation Channels Arabidopsis Proteins. Plant Cell. 2003 Feb;15(2):365-79
CNGC1 protein, Arabidopsis  0   *Cyclic Nucleotide-Gated Cation Channels Arabidopsis Proteins. Plant J. 2000 Nov;24(4):533-42
CNGC2 protein, Arabidopsis  0   *Cyclic Nucleotide-Gated Cation Channels Arabidopsis Proteins. Plant Physiol 1999 Nov;121(3):753-61
CNGC3 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclic Nucleotide-Gated Cation Channels. Plant J 1999 Apr;18(1):97-104
CNGC12 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclic Nucleotide-Gated Cation Channels. Plant Cell 2006 Mar;18(3):747-63
CNGC11 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclic Nucleotide-Gated Cation Channels. Plant Cell 2006 Mar;18(3):747-63
HCN3 protein, mouse  0   *Cyclic Nucleotide-Gated Cation Channels. Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14815-20
CNGA1 protein, bovine  0   *Cyclic Nucleotide-Gated Cation Channels. Biophys J. 2002 Dec;83(6):3283-90
HCN3 protein, human  0   *Potassium Channels *Cyclic Nucleotide-Gated Cation Channels. J Neurosci 2003 Feb 15;23(4):1169-78
CNGB3 protein, human  0   *Cyclic Nucleotide-Gated Cation Channels. Hum Mol Genet. 2000 Sep 1;9(14):2107-16
HCN4 protein, human  0   *Muscle Proteins *Cyclic Nucleotide-Gated Cation Channels. EMBO J 1999 May 4;18(9):2323-9
hyperpolarization-activated cation channel  0   *Potassium Channels *Cyclic Nucleotide-Gated Cation Channels Nerve Tissue Proteins. Nature 1998 Jun 11;393(6685):587-91
Cnga3 protein, rat  0   *Cyclic Nucleotide-Gated Cation Channels. J Biol Chem 1997 Sep 5;272(36):22623-9
Cng protein, Drosophila  0   *Calcium Channels *Drosophila Proteins *Cyclic Nucleotide-Gated Cation Channels. EMBO J 1994 Nov 1;13(21):5040-50
ivabradine  155974-00-8   *Benzazepines Stereoisomerism Cyclic Nucleotide-Gated Cation Channels. Br J Pharmacol 1994 May;112(1):37-42
ICI D2788  133059-99-1   *Pyrimidines Cyclic Nucleotide-Gated Cation Channels.
Pharma Action Cardiotonic Agents ; Cardiovascular Agents 		J Cardiovasc Pharmacol 1993 Jun;21(6):902-6
zatebradine  85175-67-3   *Benzazepines Cyclic Nucleotide-Gated Cation Channels.
Pharma Action Cardiotonic Agents 		Eur J Pharmacol 1984;104(1-2):9
CNGB1 protein, Bos taurus  0   *Nerve Tissue Proteins *Cyclic Nucleotide-Gated Cation Channels. Biochem Biophys Res Commun 1982;105(3):997
alinidine  33178-86-8   Clonidine/*analogs & derivatives Cyclic Nucleotide-Gated Cation Channels.
Pharma Action Anti-Arrhythmia Agents ; Cardiovascular Agents 		Eur J Pharmacol 58(2):141;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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