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Quinolizidines

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Definition: Saturated quinolizines that are two fused six-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to CADAVERINE. Many of them are naturally occurring ALKALOIDS.     
Examples Sparteine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lagerine N-oxide  0   *Biphenyl Compounds *Cyclic N-Oxides *Quinolizidines. Planta Med. 2011 Dec;77(18):2037-41
lagerstroemine N-oxide  0   *Biphenyl Compounds *Cyclic N-Oxides *Quinolizidines. Planta Med. 2011 Dec;77(18):2037-41
5-epi-dihydrolyfoline N-oxide  0   *Biphenyl Compounds *Cyclic N-Oxides *Quinolizidines. Planta Med. 2011 Dec;77(18):2037-41
decamine N-oxide  0   *Biphenyl Compounds *Cyclic N-Oxides *Quinolizidines Alkaloids. Planta Med. 2011 Dec;77(18):2037-41
petrosin  0   *Quinolizidines Alkaloids. Org Lett. 2010 Nov 19;12(22):5196-9
N-(1-(1-(2-carbamoylpyrrolidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2-ylamino)-4-cyclohexyl-1-oxobutan-2-yl)-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine-3-carboxamide  0   *Oligopeptides *Quinolizidines Ligands. J Pharmacol Exp Ther 2010 Mar;332(3):876-85
schulzeine A  0   *Sulfuric Acid Esters *Quinolizidines alpha-Glucosidases/antagonists & inhibitors. J Am Chem Soc 2009 May 6;131(17):6062-3
dihydrolyfoline  0   *Alkaloids *Quinolizidines Stereoisomerism. J Nat Prod 2009 Apr;72(4):749-52
lehmannine  0   *Alkaloids *Quinolizidines Drugs, Chinese Herbal. Biomed Chromatogr 2008 Oct;22(10):1149-54
cermizine D  0   *Quinolizidines. Org Lett 2008 May 15;10(10):1987-90
9-deoxy-9a-homocastanospermine  0   *Quinolizidines. Org Biomol Chem 2008 Feb 21;6(4):703-11
9a-homocastanospermine  0   *Quinolizidines. Org Biomol Chem 2008 Feb 21;6(4):703-11
1-hydroxyquinolizidinone  0   *Quinolizidines. Org Lett. 2007 Nov 8;9(23):4705-8
lutenurine  12698-70-3   *Quinolizidines. Vestn Dermatol Venerol (1):48;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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