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Peptaibols

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Definition: A group of peptides characterized by length of 1-2 dozen residues with a high proportion of them being non-proteinogenic, notably alpha-aminoisobutyric acid (Aib) and isovaline, and have a C-terminal amino alcohol and N terminal alkyl group. They are found in FUNGI and some are ANTI-INFECTIVE AGENTS. They form channels or pores in target organisms. The term is a contraction of peptide-Aib-alcohol.     
Examples Alamethicin 		Other names Trichorzianines; Emerimicin; Atroviridins; Emerimicins; Zervamicins; Culicinins; Chrysospermins; Antiamoebins; Alamethicins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
trichorovin-XIIa  0   *Peptaibols. Bioorg Med Chem Lett 2008 Jul 15;18(14):3999-4001
chrysaibol  0   *Peptaibols. J Nat Prod 2008 Sep;71(9):1600-3
septocylindrin B  0   *Peptaibols. J Nat Prod 2007 Mar;70(3):391-6
septocylindrin A  0   *Peptaibols. J Nat Prod 2007 Mar;70(3):391-6
hypomurocin A1  0   *Oligopeptides *Peptaibols. Chem Biodivers. 2005 Sep;2(9):1127-52
culicinin D  0   *Oligopeptides *Peptaibols. Nat Prod 2006 May;69(5):736-41
peptaibolin  0   *Peptaibols. J Antibiot (Tokyo) 1998 Nov;51(11):1055-8
trichorzin PA II  0   *Peptaibols. Biochim Biophys Acta 1998 Jun 24;1372(1):78-90
zervamicin IIB  79395-85-0   *Peptaibols Ion Channels. Eur Biophys J 1992;21(2):117-28
zervamicin-IC  79392-51-1   *Peptaibols Ion Channels. Eur Biophys J 1992;21(2):117-28
zervamicin A1-16  111908-11-3 L-Phenylalanine, N-((1,1-dimethylethoxy)carbonyl)-L-tryptophyl-L-isoleucyl-L-alanyl-2-methylalanyl-L-isoleucyl-L-valyl-2-methylalanyl-L-leucyl-2-methylalanyl-L-prolyl-L-alanyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-prolyl-, methyl ester  *Peptaibols Ion Channels. Eur Biophys J 1991;20(4):229-40
zervamicin Z-L  135995-68-5   *Peptaibols. Proc Natl Acad Sci USA 1991;88(12):5307
trichorzianine B  112959-01-0   *Peptaibols. Biochim Biophys Acta 1989;978(1):97
zervamicin IIA  79395-86-1   *Peptaibols. Proc Natl Acad Sci USA 1986;83(24):9284
trichorzianine A IIIc  97827-63-9   *Fungal Proteins *Peptaibols Trichoderma. Biochim Biophys Acta 1986;858(1):1
trichorzianine  88026-74-8 Trichorzianin A 1  *Peptaibols. J Mol Biol 1983;170(3):795

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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