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AMP-Activated Protein Kinases

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Definition: Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.      Other names AMP Activated Protein Kinases; AMP Activated Protein Kinase gamma Subunits; AMP Activated Protein Kinase gamma Subunit; AMP Activated Protein Kinase beta Subunits; AMP Activated Protein Kinase beta Subunit; AMP Activated Protein Kinase alpha Subunits; AMP Activated Protein Kinase alpha Subunit; AMP Activated Protein Kinase; 5' AMP Activated Protein Kinase; AMP-Activated Protein Kinase gamma Subunits; AMP-Activated Protein Kinase gamma Subunit; AMP Activated Kinase; AMP-Activated Protein Kinase beta Subunits; AMP-Activated Protein Kinase beta Subunit; AMP-Activated Protein Kinase alpha Subunits; AMP-Activated Protein Kinase alpha Subunit; AMP-Activated Protein Kinase; AMP-Activated Kinase; 5'-AMP-Activated Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-methyl-7-hydroxymethyl-1,4-naphthoquinone  0   *Naphthoquinones AMP-Activated Protein Kinases/drug effects. Fitoterapia. 2011 Dec;82(8):1285-9
RSVA405  0   *Aminophenols *Hydrazones AMP-Activated Protein Kinases. Mol Med. 2011 Sep-Oct;17(9-10):1022-30.
RSVA314  0   *Aminophenols *Hydrazones AMP-Activated Protein Kinases. Mol Med. 2011 Sep-Oct;17(9-10):1022-30.
Prkab2 protein, mouse  EC 2.7.11.1   *AMP-Activated Protein Kinases Protein Subunits. Am J Physiol Cell Physiol. 2009 Oct;297(4):C1041-52.
AMP-activated protein kinase alpha1 protein, rat  EC 2.7.11.1   *AMP-Activated Protein Kinases. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E166-73.
O2',O3',O5'-triacetyl-N6-(3-hydroxylaniline)adenosine  0   Adenosine/*analogs & derivatives AMP-Activated Protein Kinases. Lipids Health dis 2011;10:67
Prkab1 protein, mouse  EC 2.7.11.1   *AMP-Activated Protein Kinases. J Biol Chem 2010 Nov 26;285(48):37198-209
ampkinone  0   *Benzopyrans *Phthalimides AMP-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7405-13
dioxinodehydroeckol  0   *Dioxins AMP-Activated Protein Kinases/antagonists & inhibitors. Chem Biol Interact 2010 Jun 7;186(1):24-9
AMPK alpha1 subunit, mouse  EC 2.7.11.1   *AMP-Activated Protein Kinases Protein Subunits. Diabetes. 2010 Mar;59(3):554-63
Cbs2 protein, S pombe  EC 2.7.11.1   *Schizosaccharomyces pombe Proteins *AMP-Activated Protein Kinases Protein Subunits. Genes Cells 2009 May;14(5):539-54
Prkaa2 protein, rat  EC 2.7.11.1   *AMP-Activated Protein Kinases. Diabetes 2009 Sep;58(9):1953-60
AMPK alpha2 subunit, mouse  EC 2.7.11.1   *AMP-Activated Protein Kinases Protein Subunits. Mol Pharmacol 2006 Dec;70(6):1925-34
PRKAG3 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
Prkag1 protein, mouse  0   *AMP-Activated Protein Kinases.
PRKAG2 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
PRKAG1 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
Prkag3 protein, mouse  EC 2.7.11.1   *AMP-Activated Protein Kinases.
PRKAB2 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
PRKAB1 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
PRKAA2 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
PRKAA1 protein, human  EC 2.7.11.1   *AMP-Activated Protein Kinases.
SNF1A protein, Drosophila  EC 2.7.11.1   *Drosophila Proteins *AMP-Activated Protein Kinases. Sci STKE 2007 oct 6;2007(404):pe51
(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine  0   *Pyrazoles *Pyrimidines AMP-Activated Protein Kinases/antagonists & inhibitors. J Clin Invest 2001 Oct;108(8):1167-74
Nuak1 protein, rat  EC 2.7.1.-   *Protein Kinases *Repressor Proteins AMP-Activated Protein Kinases. Am J Physiol Endocrinol Metab 2005 Dec;289(6):E986-92
SNF4Agamma protein, Drosophila  EC 2.7.11.1   *Drosophila Proteins *AMP-Activated Protein Kinases.
SNF4 protein, S cerevisiae  EC 2.7.11.1   *Transcription Factors *Saccharomyces cerevisiae Proteins *AMP-Activated Protein Kinases. Genetics 1992 Nov;132(3):639-50
SIP1 protein, S cerevisiae  EC 2.7.11.1   *Saccharomyces cerevisiae Proteins *AMP-Activated Protein Kinases. Science 1992 Jul 31;257(5070):680-2

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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