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Histone Deacetylase Inhibitors

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Definition: Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.      Other names Inhibitors, Histone Deacetylase; Inhibitors, HDAC; Inhibitor, Histone Deacetylase; Deacetylase Inhibitors, Histone; Deacetylase Inhibitor, Histone; Histone Deacetylase Inhibitor; HDAC Inhibitors
Substances having this pharmacologic action: trichostatin A; vorinostat; scriptaid; N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide; apicidin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(6-dimethylamino-2-methyl-3-oxo-2,3-dihydro-benzofuran-2-yl)-4-methyl-penta-2,4-dienoic acid hydroxamide  0   *Benzofurans Histone Deacetylase Inhibitors. Curr Cancer Drug Targets. 2011 Oct;11(8):919-28
N1-4-((biphenylsulphonyl)amino)phenyl-2-amino-3-phenyl-propionamide  0   *Biphenyl Compounds *Phenylpropionates Antineoplastic Agents Histone Deacetylase Inhibitors. Yao Xue Xue Bao. 2010 Jun;45(6):735-41
kendine 92  0   *Pyrroles Histone Deacetylase Inhibitors. Epigenetics. 2011 Oct 1;6(10):1228-35
N8-hydroxy-2-(1H-indole-2-carboxamido)-N1-(quinolin-8-yl)octanediamide  0   *Aminoquinolines *Hydroxamic Acids Histone Deacetylase Inhibitors. J Periodontal Res. 2011 Dec;46(6):697-703.
6-(3-hydroxy-3-methylbutyl)-2'-(7-hydroxy-3,7-dimethyloct-3-enyl)-3',4',7-trimethoxyflavanone  0   *Monoterpenes *Flavanones Histone Deacetylase Inhibitors. J Ethnopharmacol. 2011 Jun 14;136(1):156-67.
6-(4-chlorophenylsulfanyl)-2,4-hexadienoic acid hydroxyamide  0   *Hydroxamic Acids *Sulfides Histone Deacetylase Inhibitors. Apoptosis. 2011 Sep;16(9):914-23.
refrofractamide A  0   *Amides *Benzodioxoles Histone Deacetylase Inhibitors. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4844-6.
2-(2-(3,3-dimethylbutanamido)-3-methylpentanoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylase Inhibitors. J Med Chem 2011 Aug 11;54(15):5532-9
N-hydroxy-3-(4-((2-(2-methylpyrazolo(1,5-a)pyridin-3-yl)ethylamino)methyl)phenyl)acrylamide  0   *Acrylamides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4752-72
N-hydroxy-3-(4-(((2-(2-(1-hydroxy-1-methylethyl)-1H-indol-3-yl)ethyl)isopropylamino)methyl)phenyl)acrylamide  0   *Acrylamides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4752-72
octanedioic acid (1-(3-azido-5-azidomethylbenzyl)-1H-pyrazol-4-yl)amide hydroxyamide  0   *Azides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4350-64
N-hydroxy-6-(((adamantan-1-ylamino)carbonyl)amino)hexamide  0   *Hydroxamic Acids Adamantane/*analogs & derivatives Histone Deacetylase Inhibitors. Int J Radiat Oncol Biol Phys 2011 Apr 1;79(5):1541-8
3-(2-(4-quinolin-3-yl)benzyl-1-oxoisoindolin-6-yl)-N-hydroxy-acrylamide  0   *Hydroxamic Acids *Isoindoles Histone Deacetylase Inhibitors. PLoS One 2010;5(11):e13834
3-(2-(4-pyridin-4-yl)benzyl-1-oxoisoindolin-6-yl)-N-hydroxyacrylamide  0   *Hydroxamic Acids *Isoindoles Histone Deacetylase Inhibitors. PLoS One 2010;5(11):e13834
SB939 compound  0   *Benzimidazoles Histone Deacetylase Inhibitors. Br J Cancer. 2011 Mar 1;104(5):756-62
4-(2,2-dimethyl-4-phenylbutyrylamino)-N-hydroxybenzamide  0   *Benzamides *Hydroxamic Acids Histone Deacetylase Inhibitors. PLoS One 2010;5(9):e12417
Ky-2 cyclic peptide  0   *Peptides, Cyclic Histone Deacetylase Inhibitors. Bioorg Med Chem 2004 Nov 15;12(22):5777-84
2-(6-(((6-fluoroquinolin-2-yl)methyl)amino)bicyclo(3.1.0)hex-3-yl)-N-hydroxypyrimidine-5-carboxamide  0   *Pyrimidines *Azabicyclo Compounds Histone Deacetylase Inhibitors. J Med Chem 2010 Dec 23;53(24):8663-78
kendine 91  0   *Hydroxamic Acids *Pyrroles Histone Deacetylase Inhibitors. Cancer Chemother Pharmacol 2009 Jun;64(1):153-9
N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide  0   *Benzamides *Pyridines Histone Deacetylase Inhibitors. Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4592-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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