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Cathepsin K

More information in Books or onNLM PubMed
Definition: A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.  Cathepsin X, an obsolete multi-meaning term appearing in older literature goes here or at CATHEPSIN Z: check text; Cathepsin O and Cathepsin O2 in older literature go here.   
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ONO-5334  0   *Thiazolidines Osteoporosis, Postmenopausal/drug therapy Cathepsin K/antagonists & inhibitors. J Bone Miner Res. 2011 Jun;26(6):1303-12
MK 0674  0   *Biphenyl Compounds Cathepsin K/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Feb 1;20(3):887-92
Ctsk protein, rat  EC 3.4.22.38   *Cathepsin K.
Ctsk protein, mouse  EC 3.4.22.38   *Cathepsin K.
CTSK protein, human  EC 3.4.22.38   *Cathepsin K.
procathepsin K  EC 3.4.22.-   *Cathepsin K. Protein Sci 1999 Feb;8(2):283-90

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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