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Cyclin-Dependent Kinase 8

More information in Books or onNLM PubMed
Definition: A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.      Other names Protein Kinase, Cdk8; Kinase, Cdk8 Protein; Kinase, Cdk8 Cyclin-Dependent; Cyclin-Dependent Kinase, Cdk8; Cyclin Dependent Kinase 8; Cdk8 Cyclin Dependent Kinase; Cell Division Protein Kinase 8; Cdk8 Protein Kinase; Cdk8 Cyclin-Dependent Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Cdk8 protein, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinase 8. Mol Cell Biol 2007 Sep;27(17):6177-82
CDK8 protein, Arabidopsis  EC 2.7.1.37   *Arabidopsis Proteins *Cyclin-Dependent Kinase 8. Mol Cell Biol 2007 Aug;27(15):5306-15
cdk8 protein, zebrafish  EC 2.7.1.37   *Zebrafish Proteins *Cyclin-Dependent Kinase 8.
SSN3 protein, S cerevisiae  EC 2.7.1.37   *Saccharomyces cerevisiae Proteins *Cyclin-Dependent Kinase 8.
Cdk8 protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Cyclin-Dependent Kinase 8.
srb10 protein, S pombe  EC 2.7.11.22   *Schizosaccharomyces pombe Proteins *Cyclin-Dependent Kinase 8. Yeast 1998 Mar 30;14(5):485-92
CDK8 protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinase 8. Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8871-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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