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CLOCK Proteins

More information in Books or onNLM PubMed
Definition: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.      Other names CLOCK Protein; Circadian Locomotor Output Cycles Kaput Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Clock protein, rat  EC 2.3.1.48   *CLOCK Proteins.
Clock protein, mouse  EC 2.3.1.48   *CLOCK Proteins.
CLOCK protein, human  EC 2.3.1.48   *CLOCK Proteins.
Clk protein, Drosophila  0   *Drosophila Proteins *CLOCK Proteins. Mol Cell Biol 1999 Aug;19(8):5316-25

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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