Definition: A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
Other names V erbA Related Protein EAR 1; Rev erb alpha Nuclear Receptors; Receptor NR1D1, Nuclear; Nuclear Receptors, Rev-erb-alpha; NR1D1, Nuclear Receptor; V-erbA-Related Protein EAR-1; Nuclear Receptor NR1D1; Rev-erb-alpha Nuclear Receptors
