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Orphan Nuclear Receptors

More information in Books or onNLM PubMed
Definition: A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.  do not confuse with RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS   
Examples COUP Transcription Factors; Nuclear Receptor Subfamily 1, Group D, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 2; Nuclear Receptor Subfamily 1, Group F, Member 3; Nuclear Receptor Subfamily 2, Group C, Member 1; Nuclear Receptor Subfamily 2, Group C, Member 2; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Nuclear Receptor Subfamily 4, Group A, Member 3; Nuclear Receptor Subfamily 6, Group A, Member 1; Receptors, Aryl Hydrocarbon 		Other names Receptors, Orphan Nuclear; Nuclear Receptors, Orphan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZ 876  0   *Aniline Compounds *Thiazoles Orphan Nuclear Receptors/agonists. Br J Pharmacol 2011 Apr;162(7):1553-63
Nr2e3 protein, mouse  0   *Orphan Nuclear Receptors Eye Proteins.
liver X receptor  0   *Orphan Nuclear Receptors. Mol Pharmacol 2002 Dec;62(6):1299-305
NR2E3 protein, human  0   *Orphan Nuclear Receptors Eye Proteins. Nat Genet 2000 Feb;24(2):127-31; Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15149-54; Proc Natl Acad Sci U S A 2000 May 9;97(10):5551-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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