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Single-Chain Antibodies

More information in Books or onNLM PubMed
Definition: A form of antibodies consisting only of the variable regions of the heavy and light chains, connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.      Other names Variable Fragments, Single-Chain; Variable Fragment, Single-Chain; Single Chain Variable Fragments; Single Chain Variable Fragment Antibody; Single Chain Variable Fragment Antibodies; Single Chain Variable Fragment; Single Chain Fv Antibody; Single Chain Fv; Single Chain Antibodies; Fv Antibody, Single-Chain; Fragments, Single-Chain Variable; Fragment, Single-Chain Variable; Fv, Single-Chain; Antibody, Single-Chain Fv; Antibodies, Single-Chain; Antibodies, ScFv; Single-Chain Variable Fragments; Single-Chain Variable Fragment Antibody; Single-Chain Variable Fragment Antibodies; Single-Chain Variable Fragment
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
immunoRNase scFv 4D5-dibarnase  0   *Recombinant Fusion Proteins *Ribonucleases Single-Chain Antibodies. Invest New Drugs 2011 Feb;29(1):22-32
m9 antibody  0   *Single-Chain Antibodies Anti-HIV Agents. MAbs. 2010 May;2(3):266-74
scFvCD33-sTRAIL protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Leukemia 2009 Aug;23(8):1389-97
scFvRit-sFasL protein, human  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Cancer Res 2008 Jan 15;68(2):597-604
ScFv CB4-1  0   *Single-Chain Antibodies. J Mol Recognit 2007 Mar-Apr;20(2):97-102
scHLA-A2 scFv 225 fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Int J Cancer 2007 Jan 15;120(2):329-36
425(scFv)-ETA'  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Int J Oncol 2003 Oct;23(4):1179-86
scFvMEL-TNF fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Neoplasia 2006 May;8(5):384-93
ScFv(G250) protein  0   *Receptors, Immunologic *Single-Chain Antibodies. Cancer Gene Ther 2006 May;13(5):503-9
MT110 monoclonal antibody  0   *Single-Chain Antibodies. Mol Immunol 2006 Mar;43(8):1129-43
scFv(FRP5)-ETA antibody toxin  0   *Exotoxins *Recombinant Fusion Proteins *Single-Chain Antibodies. Breast Cancer Res 2005;7(5):R617-26
ScFv23-TNF fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Mol Cancer Ther 2005 Aug;4(8):1205-13
ScFv(L19)-interferon-gamma  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Int J Cancer 2005 Aug 20;116(2):304-13
scFvC54-sTRAIL fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies Immunoglobulin Variable Region. Neoplasia 2004 Sep-Oct;6(5):636-45
scFv-CD28-zeta chimeric receptor  0   *Receptors, Cell Surface *Recombinant Fusion Proteins *Single-Chain Antibodies. Hum Gene Ther 2004 Jul;15(7):699-708
Ki-3(scFv)-ETA'  0   *Single-Chain Antibodies Immunotoxins. Int J Cancer 2004 Sep 10;111(4);568-74
monoclonal antibody scFv A21  0   *Single-Chain Antibodies. Cell Res 2003 Feb;13(1):35-48
Hep27scFv  0   *Single-Chain Antibodies. BMC Biotechnol 2002 Sep 12;2(1);16
mAb K2-3f scFv antibody  0   *Single-Chain Antibodies. Biochim Biophys Acta. 2003 Jul 30;1638(3):257-66
Nd-1scFv  0   *Single-Chain Antibodies. World J Gastroenterol 2003 Apr;9(4):726-30
5.2-OKT3 bispecific single-chain antibody fragment  0   *Antibodies, Bispecific *Single-Chain Antibodies. Blood 2003 Mar 15;101(6):2300-6
p53 TCR scFv-P38 fusion protein, recombinant  0   *Recombinant Fusion Proteins *Single-Chain Antibodies. Cancer Immunol Immunother 2002 Nov;51(10):565-73
TNF-selectokine  0   *Tumor Necrosis Factor-alpha *Single-Chain Antibodies. Oncogene 2002 Jun 20;21(27):4257-65
single chain Fv fragment M97  0   *Single-Chain Antibodies. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1998 Apr;20(2):81-8
SP31 ScFv  0   *Single-Chain Antibodies Recombinant Proteins Substance P. Anal Biochem 2000 Sep 10;284(2):221-30
ScFv VK34  0   *Single-Chain Antibodies. Blood 2000 Jul 15;96(2):540-5
ScFv VK41  0   *Single-Chain Antibodies. Blood 2000 Jul 15;96(2):540-5
scFV green fluorescent protein, recombinant  0   *Recombinant Fusion Proteins *Green Fluorescent Proteins *Single-Chain Antibodies Fluorescent Dyes. J Biol Chem 2000 Jun 9;275(23):17556-60
pexelizumab  0   *Single-Chain Antibodies *Antibodies, Monoclonal, Humanized. Circulation 1999 Dec 21-28;100(25):2499-506
scFv 763.74  0   *Single-Chain Antibodies Immunoglobulin Fragments. J Invest Dermatol 1999 May;112(5):744-50
RFT5(scFv)-ETA'  0   *Single-Chain Antibodies Immunotoxins. Int J Mol Med 1998 Jan;1(1):249-56
anti-quadruplex DNA scFv  0   *Antibodies, Antinuclear *Single-Chain Antibodies DNA-Binding Proteins Immunoglobulin Variable Region. Biochemistry 1998 Nov 17;37(46);16316-24
BMS-191352 protein, recombinant  0   *Bacterial Toxins *Exotoxins *Recombinant Fusion Proteins *ADP Ribose Transferases *Single-Chain Antibodies Immunotoxins. J Immunoassay 1998 May-Aug;19(2-3):145-65
scFv fragment SW1  0   *Single-Chain Antibodies. Biochemistry 1998 Sep 15;37(37):13011-20
scFv 425  0   *Single-Chain Antibodies. FEBS Lett 1998 Jul 31;432(1-2):45-9
GD5 protein, recombinant  0   *Diphtheria Toxin *Recombinant Fusion Proteins *Receptor, erbB-2 *Single-Chain Antibodies Genetic Vectors. J Biol Chem 1998 Apr 10;273(15):8835-41
CEA 79 scFv  0   *Single-Chain Antibodies. Mol Cells 1997 Dec 31;7(6):816-9
FVS191Cys-(scFv')2  0   *Single-Chain Antibodies. Bioconjug Chem 1997 Jan-Feb;8(1):64-70
recombinant antibody scFV2913  0   *Recombinant Proteins *Single-Chain Antibodies. Anticancer Res 1996 Nov-Dec;16(6B):3551-6
scFv 421  0   *Single-Chain Antibodies. Biochem Biophys Res Commun 1997 Jan 13;230(2):242-6
EDNsFv anti-transferrin receptor  0   *Single-Chain Antibodies Recombinant Fusion Proteins Immunotoxins Neurotoxins Receptors, Transferrin. J Biol Chem 1994 Oct 28;269(43):26739-45
OLX 209  0   *Exotoxins *Single-Chain Antibodies Recombinant Fusion Proteins Immunotoxins. Adv Enzyme Regul 1994;34:119-28
glycoprotein EO, classical swine fever virus  EC 3. 1.-   *Ribonucleases *Viral Structural Proteins *Single-Chain Antibodies. Science 1993 Aug 27;261(5125):1169-71

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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