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GPI-Linked Proteins

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Definition: A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.     
Examples Antigens, CD14; Antigens, CD24; Antigens, CD55; Antigens, CD59; Carbonic Anhydrase IV; Ciliary Neurotrophic Factor Receptor alpha Subunit; Contactins; Ephrin-A1; Ephrin-A2; Ephrin-A3; Ephrin-A4; Ephrin-A5; Folate Receptors, GPI-Anchored; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glypicans; Matrix Metalloproteinase 17; Uromodulin 		Other names Proteins, Glycosylphosphatidylinositol Linked; Proteins, GPI-Linked Membrane; Proteins, GPI-Linked; Membrane Proteins, GPI-Linked; Linked Proteins, Glycosylphosphatidylinositol; GPI Linked Proteins; GPI Linked Membrane Proteins; Glycosylphosphatidylinositol Linked Proteins; GPI-Linked Membrane Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C4.4A protein, rat  0   *Neoplasm Proteins *GPI-Linked Proteins. Oncogene. 1998 Oct 15;17(15):1989-2002.
MDGA2 protein, mouse  0   *Neural Cell Adhesion Molecules *GPI-Linked Proteins. Biochem Biophys Res Commun. 2012 Feb 17;418(3):439-44
Nogo receptor 2, mouse  0   *Receptors, Cell Surface GPI-Linked Proteins. EMBO J. 2003 Jul 1;22(13):3291-302.
netrin-G3 ligand protein, human  0   *Nerve Tissue Proteins *GPI-Linked Proteins. EMBO J. 2011 Sep 23;30(21):4479-88
QUASIMODO protein, Drosophila  0   *Drosophila Proteins *GPI-Linked Proteins Circadian Clocks. Curr Biol. 2011 May 10;21(9):719-29
Omg protein, rat  0   *Myelin Proteins *GPI-Linked Proteins.
Omg protein, mouse  0   *Myelin Proteins *GPI-Linked Proteins.
OMG protein, human  0   *Myelin Proteins *GPI-Linked Proteins.
LYPD3 protein, mouse  0   *Cell Adhesion Molecules *GPI-Linked Proteins. J Histochem Cytochem. 2011 Feb;59(2):188-201
Ly6k protein, mouse  0   *Antigens, Ly GPI-Linked Proteins. Biochem Biophys Res Commun 2010 Nov 5;402(1):75-81
dipeptidase 1  EC 3.4.13.19   *Dipeptidases GPI-Linked Proteins.
ALPPL2 protein, human  EC 3.1.3.1   *Alkaline Phosphatase GPI-Linked Proteins.
Ache protein, rat  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
Ache protein, mouse  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
ACHE protein, human  EC 3.1.1.7   *Acetylcholinesterase GPI-Linked Proteins.
Nt5e protein, rat  EC 3.1.3.5   *5'-Nucleotidase GPI-Linked Proteins.
Nt5e protein, mouse  EC 3.1.3.5   *5'-Nucleotidase GPI-Linked Proteins.
NT5E protein, human  EC 3.1.3.5   *5'-Nucleotidase GPI-Linked Proteins.
MDGA2 protein, human  0   *Neural Cell Adhesion Molecules *GPI-Linked Proteins. Psychiatr Genet. 2009 Aug;19(4):213-4
Reck protein, rat  0   *Tumor Suppressor Proteins GPI-Linked Proteins. J Mol Histol 2008 Apr;39(2):201-8
CEACAM5 protein, human  0   *Carcinoembryonic Antigen GPI-Linked Proteins. Oncogene 2008 Jan 24;27(5):675-83
LY6K protein, human  0   *Antigens, Ly GPI-Linked Proteins. Cancer Res 2007 Dec 15;67(24):11601-11
RGMA protein, human  0   *Nerve Tissue Proteins GPI-Linked Proteins. J Biol Chem 2007 Jun 22;282(25):18129-40
Bst2 protein, rat  0   *Antigens, Surface GPI-Linked Proteins.
Cd160 protein, mouse  0   *Receptors, Immunologic *Antigens, CD GPI-Linked Proteins.
Vnn3 protein, mouse  EC 3.5.1.92   *Amidohydrolases *Cell Adhesion Molecules GPI-Linked Proteins.
LYPD1 protein, human  0   *Tumor Suppressor Proteins GPI-Linked Proteins. Exp Cell Res 2006 Apr 1;312(6):865-76
Psca protein, mouse  0   *Antigens, Neoplasm *Neoplasm Proteins GPI-Linked Proteins.
CEACAM8 protein, human  0   *Antigens, CD *Cell Adhesion Molecules GPI-Linked Proteins.
CEACAM6 protein, human  0   *Antigens, CD *Cell Adhesion Molecules GPI-Linked Proteins.
Gas1 protein, rat  0   *Cell Cycle Proteins GPI-Linked Proteins.
Gas1 protein, mouse  0   *Cell Cycle Proteins GPI-Linked Proteins.
PRND protein, human  0   *Prions GPI-Linked Proteins.
Gp2 protein, mouse  0   *GPI-Linked Proteins. J Biol Chem 2004 Nov 26;279(48):50274-9
Reck protein, mouse  0   *GPI-Linked Proteins.
TECTA protein, human  0   *Extracellular Matrix Proteins GPI-Linked Proteins.
tdgf1 protein, Xenopus  0   *Xenopus Proteins *Intercellular Signaling Peptides and Proteins *GPI-Linked Proteins.
GP2 protein, human  0   *GPI-Linked Proteins Cytoplasmic Granules.
Opcml protein, rat  0   *Cell Adhesion Molecules GPI-Linked Proteins Nerve Tissue Proteins.
Opcml protein, mouse  0   *Cell Adhesion Molecules GPI-Linked Proteins Nerve Tissue Proteins.
MDGA1 protein, rat  0   *Immunoglobulins GPI-Linked Proteins. Mol Cell Neurosci 2004 Feb;25(2):263-74
Otoa protein, mouse  0   *GPI-Linked Proteins.
Rtn4r protein, rat  0   *Myelin Proteins *Receptors, Cell Surface GPI-Linked Proteins.
RTN4R protein, human  0   *Myelin Proteins *Receptors, Cell Surface GPI-Linked Proteins.
LYNX1 protein, human  0   *GPI-Linked Proteins Neuropeptides.
NEGR1 protein, human  0   *Cell Adhesion Molecules, Neuronal GPI-Linked Proteins.
NRN1 protein, human  0   *Neuropeptides GPI-Linked Proteins.
Nrn1 protein, mouse  0   *Nerve Tissue Proteins GPI-Linked Proteins. Mol Cell Neurosci 2003 Nov;24(3):538-54
Rgma protein, mouse  0   *Nerve Tissue Proteins GPI-Linked Proteins. J Neurosci 2004 Jan 28;24(4):808-18
HFE2 protein, human  0   *GPI-Linked Proteins Hemochromatosis. Nat Genet 2004 Jan;36(1):77-82
SPRN protein, human  0   *Nerve Tissue Proteins *GPI-Linked Proteins. Biochem Biophys Res Commun 2003 Oct 17:310(2):89-102
RTN4RL1 protein, human  0   *Receptors, Cell Surface GPI-Linked Proteins. J Neurochem 2003 May;85(3):717-28
RTN4RL2 protein, human  0   *Receptors, Cell Surface GPI-Linked Proteins. J Neurochem 2003 May;85(3):717-28
Hyal2 protein, human  EC 3.2.1.25   *Hyaluronoglucosaminidase *Cell Adhesion Molecules GPI-Linked Proteins Receptors, Virus. Curr Top Microbiol Immunol 2003;275:179-99
LYPD3 protein, human  0   *Cell Adhesion Molecules GPI-Linked Proteins. Br J Cancer 2003 Feb 24;88(4):579-85
Hyal2 protein, mouse  EC 3.2.1.35   *Hyaluronoglucosaminidase GPI-Linked Proteins. BMC Cell Biol 2002 Apr 3;3(1):8
NTNG2 protein, human  0   *Nerve Tissue Proteins *GPI-Linked Proteins. Mol Cell Neurosci 2002 Mar;19(3):344-58
NTNG1 protein, human  0   *Nerve Tissue Proteins GPI-Linked Proteins. Mol Cell Neurosci 2002 Mar;19(3):344-58
MDGA1 protein, human  0   *Cell Adhesion Molecules GPI-Linked Proteins. Oncogene 2002 May 2;21(19):3089-94
Prss21 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases GPI-Linked Proteins. J Biol Chem 2002 May 10;277(19):16976-84
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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