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Adenosine A2 Receptor Antagonists

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Definition: Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.      Other names Adenosine A2B Receptor Antagonists; Adenosine A2A Receptor Antagonists
Substances having this pharmacologic action: enprofylline; istradefylline; regadenoson; 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine; 3,7-dimethyl-1-propargylxanthine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists. J Med Chem. 2012 Feb 9;55(3):1402-17.
2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists. J Med Chem. 2012 Feb 9;55(3):1402-17.
8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide  0   *Hydrazines *Bicyclo Compounds, Heterocyclic Adenosine A2 Receptor Antagonists. Chem Biol Interact. 2012 Jan 5;195(1):18-24.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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