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Topoisomerase Inhibitors

More information in Books or onNLM PubMed
Definition: Compounds that inhibit the activity of DNA TOPOISOMERASES.     
Examples Topoisomerase I Inhibitors; Topoisomerase II Inhibitors 		Other names Topoisomerase Inhibitors, DNA; Inhibitors, Topoisomerase; Inhibitors, DNA Topoisomerase; DNA Topoisomerase Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
D11 compound  0   *Lignans *Glucosides DNA Topoisomerases, Type II Topoisomerase Inhibitors. Invest New Drugs. 2011 Oct;29(5):800-10.
BNS 22  0   *Coumarins *Quinolines DNA Topoisomerases, Type II Topoisomerase Inhibitors. Chem Biol 2011 Jun 24;18(6):
(eta6-p-cymene)ruthenium(2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide)  0   *Coordination Complexes DNA Topoisomerases, Type II Topoisomerase Inhibitors. Metallomics 2011 May 1;3(5):491-502
3-(2-(dimethylamino)ethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):
3-(diethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):4077-91
12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo(4,5)cyclohepta(1,2-b)naphthalen-5,12-imine  0   *Naphthoquinones DNA Topoisomerases, Type II DNA Topoisomerases, Type I Topoisomerase Inhibitors. Biochem Biophys Res Commun 2011 Apr 29;408(1):94-8
G3 PAMAM-NH2 dendrimer-modified digoxin  0   *Digoxin *Dendrimers Topoisomerase Inhibitors. Acta Pol Pharm. 2010 Nov-Dec;67(6):630-4
G3 PAMAM-NH2 dendrimer-modified proscillaridin A  0   *Proscillaridin *Dendrimers Topoisomerase Inhibitors. Acta Pol Pharm. 2010 Nov-Dec;67(6):630-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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