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Cholecalciferol
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Definition
: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
deficiency: coordinate CHOLECALCIFEROL /defic (IM) with VITAMIN D DEFICIENCY (IM)
Pharmacological Action
Bone Density Conservation Agents
;
Vitamins
See Also
Receptors, Calcitriol
Examples
Hydroxycholecalciferols
Other names
Vitamin D 3; Vitamin D3; Cholecalciferols; Calciol; (3 beta,5Z,7E)-
9,10-
Secocholesta-
5,7,10(19)-
trien
Substance
CAS Registry & name
Categories
Source
Drugs
*
19-
nor-
2-
(3-
hydroxypropyl)-
1,25-
dihydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Steroids. 2011 Dec 11;76(13):1513-9.
1,25-
dihydroxy-
26-
(hydroxymethyl)vitamin D3
0
Cholecalciferol/*analogs & derivatives.
J Med Chem 2011 Jun 9;54(11):3950-62
1,25-
dihydroxy-
26-
(hydroxymethyl)-
26-
methylvitamin D3
0
Cholecalciferol/*analogs & derivatives.
J Med Chem 2011 Jun 9;54(11):3950-62
17,20-
dihydroxypregnacalciferol-
3,17,20-
trihydroxy-
9,10-
secopregna-
5,7,10-
triene
0
Cholecalciferol/*analogs & derivatives.
J Invest Dermatol 2011 May;131(5):1167-9
MF Afragil
0
*Carotenoids
*Cholecalciferol
*Flavonoids
*Xanthophylls
Drug Combinations.
Panminerva Med 2010 jan;52(2 Suppl 1):49-54
22-
butyl-
1,24-
dihydroxy-
24,25,26-
trinorvitamin D3
0
Cholecalciferol/*analogs & derivatives
Receptors, Calcitriol/antagonists & inhibitors
Receptors, Calcitriol/agonists.
J Med Chem 2009 Mar 12;52(5):1438-49
SMD-
429
0
Cholecalciferol/*analogs & derivatives.
Int J Pharm 2008 Apr 2;353(1-2):105-12
HY-
11
0
Cholecalciferol/*analogs & derivatives.
Int J Oncol 2008 Feb;32(2):387-96
HUM 5007
0
*Cholecalciferol
*Ascorbic Acid
*Nicotinic Acids
*Plant Extracts
Dehydroepiandrosterone/*analogs & derivatives.
J Nutr Biochem 2007 Sep;18(9):629-34
NT020 formula
0
*Carnosine
*Cholecalciferol
*Plant Extracts.
Rejuvenation Res 2007 Jun;10(2):173-8
2-
(3-
hydroxypropoxy)-
24-
propylvitamin D3-
26,23-
lactone
0
Cholecalciferol/*analogs & derivatives
Receptors, Calcitriol.
J Med Chem 2006 Nov 30;49(24):7063-75
1,25-
dihydroxy-
20S-
21(3-
hydroxy-
3-
methyl-
butyl)-
23-
yne-
26,27-
hexafluoro-
vitamin D3
0
Cholecalciferol/*analogs & derivatives.
J Steroid Biochem Mol Biol 2006 Aug;100(4-5):107-16
C-
9,11-
bisnor-
17-
methyl-
1, 25-
dihydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Bioorg Med Chem Lett 2002 Jun 17;12(12):1633-6
C-
9,11,21-
trisnor-
17-
methyl-
1, 25-
dihydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Bioorg Med Chem Lett 2002 Jun 17;12(12):1629-32
4,4-
difluoro-
1,25-
dihydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Chem Pharm Bull (Tokyo) 2002 Apr;50(4):475-83
1,15-
dihydroxy-
16-
ene-
19-
nor-
24-
oxovitamin D3
0
Cholecalciferol/*analogs & derivatives.
Cancer Res 2002 Feb 1;62(3):741-6
1,25-
dihydroxy-
22-
ene-
vitamin D3
0
Cholecalciferol/*analogs & derivatives.
J Steroid Biochem Mol Biol 2001 Aug;78(2):167-76
ILX237553
0
Cholecalciferol/*analogs & derivatives.
Cancer Chemother Pharmacol 2001 May;47(5):429-36
2-
hydroxypropyl-
1,25-
dihydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Bioorg Med Chem Lett 2000 May 15;10(10):1129-32
TX 522
0
*Alkynes
*Cholecalciferol
Stereoisomerism.
Cancer Res 2000 May 15;60(10):2673-9
1,25(OH)2-
16-
ene-
23-
yne-
26,27-
hexafluoro-
19-
nor-
D3
0
Cholecalciferol/*analogs & derivatives
Calcitriol.
Biochem Biophys Res Commun 2000 Apr 21;270(3):701-8
1,23-
dihydroxy-
24-
oxovitamin D3
0
Cholecalciferol/*analogs & derivatives.
Biochem Pharmacol 1999 Dec 15;58(12):1965-73
1-
hydroxy-
24-
oxovitamin D3
0
Cholecalciferol/*analogs & derivatives.
Biochem Pharmacol 1999 Dec 15;58(12):1965-73
1,25-
dihydroxy-
16,23-
diene vitamin D3
0
Cholecalciferol/*analogs & derivatives.
Bioorg Med Chem 1998 Nov;6(11):2051-9
25-
hydroxy-
16,23-
diene vitamin D3
0
Cholecalciferol/*analogs & derivatives.
Bioorg Med Chem 1998 Nov;6(11):2051-9
Ro 25-
6760
0
Cholecalciferol/*analogs & derivatives.
Anticancer Res 1998 May-Jun;18(3A):1703-8
1-
hydroxy-
25,26,27-
trinorvitamin D3 24-
oic acid
0
Cholecalciferol/*analogs & derivatives
Haptens.
Biol Pharm Bull 1997 Sep;20(9):948-53
25-
hydroxyvitamin D3 3-
hemisuccinate
0
*Succinates
Cholecalciferol/*analogs & derivatives
Haptens.
Biol Pharm Bull 1997 Sep;20(9):948-53
19-
nor-
hexafluoride vitamin D3
0
Cholecalciferol/*analogs & derivatives.
J Mol Endocrinol 1997 Aug;19(1):15-27
Ro 24-
2090
0
Cholecalciferol/*analogs & derivatives.
Anal Biochem 1996 Dec 1;243(1):28-40
2-
methoxy-
1,26-
dihydroxy-
27-
norvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Steroids 1996 Oct;61(10):598-608
1,26-
dihydroxy-
27-
norvitamin D3
0
Cholecalciferol/*analogs & derivatives.
Steroids 1996 Oct;61(10):598-608
Ossofortin
0
*Calcium Gluconate
*Calcium Phosphates
*Cholecalciferol
Drug Combinations.
Dtsch Med Wochenschr 1996 Mar 15;121(11):356-7
24-
oxa-
1-
hydroxyvitamin D3
0
Cholecalciferol/*analogs & derivatives
Cholecalciferol/antagonists & inhibitors.
Steroids 1995 Jun;60(6):484-90
24-
oxavitamin D3
0
Cholecalciferol/*analogs & derivatives
Cholecalciferol/antagonists & inhibitors.
Steroids 1995 Jun;60(6):484-90
25-
hydroxyvitamin D3-
3-
(1,2-
epoxypropyl)ether
0
Cholecalciferol/*analogs & derivatives
Tritium.
Arch Biochem Biophys 1995 Jun 1;319(2):504-7
1,25-
dihydroxy-
19-
norprevitamin D3
144699-06-9
*Cholecalciferol.
J Bone Miner Res 1993 Aug;8(8):1009-15
22-
fluorovitamin D3
110536-31-7 9,10-
Secocholesta-
5,7,10(19)-
trien-
3-
ol, 22-
fluoro-
, (3beta,5Z,7E)
Cholecalciferol/*analogs & derivatives.
Steroids 1987;48(1-2):93
2-
fluorovitamin D3
103638-37-5
Cholecalciferol/*analogs & derivatives.
Chem Pharm Bull (Tokyo) 1986;34(4):1568
3-
thiovitamin D3
98353-78-7
Cholecalciferol/*analogs & derivatives.
J Steroid Biochem 1985;23(1):81
10-
ketovitamin D3
95480-84-5 19-
Nor-
9,10-
secocholesta-
5,7-
dien-
4-
one, 1-
hydroxy-
, (1alpha,5Z,7E)
Cholecalciferol/*analogs & derivatives.
Arch Biochem Biophys 1985;236(2):555
6-
fluorovitamin D3
91625-75-1 9,10-
Secocholesta-
5,7,10(19)-
trien-
3-
ol, 6-
fluoro-
, (3beta,5E,7E)
Cholecalciferol/*analogs & derivatives.
Arch Biochem Biophys 1984;233(1):127
19-
nor-
10-
ketovitamin D3
62743-72-0
Cholecalciferol/*analogs & derivatives.
Biochemistry 1983;22(15):3636
vitamin D3 butyrate
31316-20-8 9,10-
Secocholesta-
5,7,10(19)-
trien-
3-
ol, butanoate, (3beta,5Z,7E)
Cholecalciferol/*analogs & derivatives.
Int J Vitam Nutr Res 1981;51(4):353
vitamin D3 palmitate
13403-10-6
Cholecalciferol/*analogs & derivatives.
Int J Vitam Nutr Res 1981;51(4):353
vitamin D3 glucosiduronate
0
Cholecalciferol/*analogs & derivatives.
J Clin Invest 1980;66(6):1274
vitamin D3 sulfoconjugate
10529-43-8 9,10-
Secocholesta-
5,7,10(19)-
trien-
3-
ol, hydrogen sulfate, (3beta,5Z,7E)