encyclopedia of medical concepts
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mezerein

under Diterpenes
More information in Books or onNLM PubMed
More on Diterpenes Definition: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.  GEN; prefer specifics    Other names Norditerpenes; Diterpenes, Labdane; Diterpenes, Cembrane; Labdane Diterpenes; Cembrane Diterpenes; Norditerpenoids; Labdanes; Diterpenoids; Cembranes
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mezerein [ 1alpha-alkyldaphnane,5-phenyl-2,4-pentadionate daphnetoxin,daphnane ]
  toxic component of plant Daphne mezereum with anti-leukemic activity against P-388 & P-1210 in mice; can act as a tumor promoter; RN given refers to (12beta(E,E))-isomer; structure 		34807-41-5   *Diterpenes
Pharma Action Antineoplastic Agents, Phytogenic; Carcinogens 		Cancer Res 1979;39(12):4791; Cancer Res 1979;39(9):3602; Cancer Res 38:771;1978; Nature 257(5529):824;1975; Science 204(4395):868;1979; Z Naturforsch (C) 32(9-10):678;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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