Definition: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
don't confuse with SIGNAL PEPTIDES entry term to PROTEIN SORTING SIGNALS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS is also available
protein kinase modulator [ PKA inhibitor,cAMP-dependent protein kinase protein modulator,cGK Ibeta,cGKIbeta,cGMP-dependent protein kinase protein modulator,cyclic AMP-dependent protein kinase inhibitor,megamodulin,protein kinase inhibitor type I,protein kinase stimulatory modulator ] stimulates phosphorylation of histones by mammalian cGPK & inhibits phosphorylation by cAPK; stimulates & inhibits protein kinase; see also records for PKIbeta and PKIgamma
