histidyl-proline diketopiperazine (definition)

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ψ ψ	histidyl-proline diketopiperazine under Peptides, Cyclic

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Definition: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).

Other names Cyclic Peptides

Substance	CAS Registry & name	Categories	Source	Drugs*
histidyl-proline diketopiperazine [ His-Pro-Dkp,cyclo(His-Pro),cyclo(histidyl-prolyl),histidyl-proline diketopiperazine, (3R-cis)-isomer,histidyl-proline diketopiperazine, (3S-cis)-isomer,histidyl-proline diketopiperazine, (3S-trans)-isomer,histidyl-proline-diketopiperazine ] biologically active cpd to which thyrotropin-releasing hormone (TRH) is metabolized; structure; RN given refers to cpd without isomeric designation	4257-92-5 Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S-trans)	Peptides, Cyclic Piperazines Pharma Action Antioxidants; Neurotransmitter Uptake Inhibitors	Biochem Biophys Res Commun 85(4):1582;1978; Eur J Pharmacol l979;58(1):97; Nature 268(5616):142;1977; Nature 274(5667):174;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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