Definition: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Other names MK933; MK 933; Ivermectin Merck Brand; Stromectol; Merck Brand of Ivermectin; Mectizan; MK-933; Ivomec; Eqvalan
avermectin [ avermectin A1a,avermectins,aversectin C ] produced by actinomycete, Streptomyces avermitilis; structure; see also records for specific avermectins
Am J Vet Res 1979;40(7):1031; Am J Vet Res 1979;40(8):1187; Antimicrob Agents Chemother 15(3):361;1979; Eur J Pharmacol 56(3):273;1979; J Helminthol 52(4):305;1979; J Helminthol 52(4):308;1979; Proc Natl Acad Sci USA 76(4):2062;1979; Vet Rec 1979;105(8):168; Vet Rec 1980;108(3):59
