Definition: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Other names Angiotensin II, Val(5); Angiotensin II, Ile(5); II, 5-L-Isoleucine Angiotensin; Angiotensin II, 5-L-Isoleucine; 5 L Isoleucine Angiotensin II; Valyl(5)-Angiotensin II; Isoleucyl(5)-Angiotensin II; Isoleucine(5)-Angiotensin; Angiotensin-(1-8) Octapeptide; Angiotensin II, Valine(5); Angiotensin II, Isoleucine(5); ANG-(1-8)Octapeptide; 5-L-Isoleucine Angiotensin II
angiotensin II, Sar(1)-Ile(5)- [ 1-Sar-5-Ile-angiotensin II,S1-AII,angiotensin II, Sar(1)-Ile(5)-, (5-L-allo-Ile)-isomer,angiotensin II, Sar(1)-Ile(5)-, (7-D-Pro)-isomer,angiotensin II, sarcosyl(1)-isoleucine(5)- ] RN given refers to (5-L-Ile)-isomer