Definition: THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
ciglitazone [ 5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione,ADD 3878,ADD-3878,ciglitizone ] structure given in second source; PPAR agonist used for type II diabetes