encyclopedia of medical concepts
ψ
ψ
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acetorphan
under Thiorphan
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Thiorphan
Definition
: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Other names
Thiorphan, (S)-
Isomer; Thiorphan, (R)-
Isomer; (3-
Mercapto-
2-
benzylpropionyl)glycine; Tiorphan
Substance
CAS Registry & name
Categories
Source
Drugs
*
acetorphan [ N-(3-acetylmercapto-2-benzylpropanoyl)glycine benzyl ester,acetorphan, (R)-isomer,acetorphan, (S)-isomer,ecadotril,racecadotril,retorphan,sinorphan ]
parenterally active enkephalinase inhibitor
81110-73-8 Glycine, N-
(2-
((acetylthio)methyl)-
1-
oxo-
3-
phenylpropyl)-
, phenylmethyl ester, (+-
)
Thiorphan/*analogs & derivatives
Neprilysin/antagonists & inhibitors
Pharma Action
Antidiarrheals
;
Protease Inhibitors
J Pharmacol Exp Ther 1986;237(3):937