Definition: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
antivirals & antimetabolites
Other names Dideoxyribonucleosides; 2',3'-Dideoxynucleosides; 2',3' Dideoxynucleosides; ddNus