Definition: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
desirudin [ Aventis Pharma brand of desirudin,Aventis brand of desirudin,CGP 39393,CGP-39393,IK-HIR02,Iprivask,Novartis brand of desirudin,Revasc,desulfatohirudin,desulphatohirudin,recombinant HV1 hirudin ] recombinant hirudin; has identical amino acid sequence as the natural hirudin variant 1 but lacks the sulphate group on Tyr(63)