Definition: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
bivalirudin [ Angiomax,BG 8967,BG-8967,BG8967,Hirulog,Hirulog-1,Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen,Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu,Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64),The Medicines Company brand of bivalirudin ] designed to bind to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition
