Definition: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
lepirudin [ 1-Leu-2-Thr-63-desulfohirudin,Aventis Behring Brand of Lepirudin,Aventis Brand Lepirudin,Aventis Pharma Brand of Lepirudin,Berlex Brand of Lepirudin,HBW 023,HBW-023,Hoechst Brand of Lepirudin,Pharmion Brand of Lepirudin,Refludan,Refludin,Schering Brand of Lepirudin ]
