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DNASE1 protein, human

under Deoxyribonuclease I
More information in Books or onNLM PubMed
More on Deoxyribonuclease I Definition: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.  do not confuse X ref STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE: see note there; DF: note short X ref    Other names Streptodornase; DNase I; T7 Endonuclease I; T4 Endonuclease II; Endonuclease, DNA; DNase, Pancreatic; Thymonuclease; T7-Endonuclease I; T4-Endonuclease II; Pancreatic DNase; Nickase; Endonuclease I; Dornavac; DNAase I; DNA Nicking Enzyme; DNA Endonuclease
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DNASE1 protein, human [ Genentech brand of dornase alfa,Hoffmann-La Roche brand of dornase alfa,Pulmozyme,rhDNase,Roche brand of dornase alfa,deoxyribonuclease I, human,dornase alfa,dornase alpha,recombinant human DNase,recombinant human deoxyribonuclease I ]
  RefSeq NM_005223 		EC 3.1.21.1   *Deoxyribonuclease I Cystic Fibrosis JAMA 1994 Feb 16;271(7):494 PULMOZYME

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