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ψ
ψ
romidepsin
under Depsipeptides
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Depsipeptides
Definition
: Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
Other names
Cyclic Depsipeptides; Depsipeptides, Cyclic; Cyclodepsipeptides; Cryptophycins
Substance
CAS Registry & name
Categories
Source
Drugs
*
romidepsin [ FK228,Astella Pharma Brand of romidepsin,FR 901228,FR-901228,FR901228,istodax ]
a bicyclic depsipeptide and a potent histone deacetylase inhibitor from Chromobacterium violaceum; structure in first source
128517-07-7 L-
Valine, N-
(3-
hydroxy-
7-
mercapto-
1-
oxo-
4-
heptenyl)-
D-
valyl-
D-
cysteinyl-
(Z)-
2,3-
didehydro-
2-
aminobutanoyl-
, xi-
lactone, cyclic (1-
2)-
disulfide, (S-
(E))
*Depsipeptides
Pharma Action
Antibiotics, Antineoplastic
J Antibiot (Tokyo) 1994 Mar;47(3):301-10
ISTODAX