Definition: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
15-deoxy-delta(12,14)-prostaglandin J2 [ 15-deoxy-12,14-prostaglandin J2,15-deoxy-delta(12,14)PGJ2,15-deoxy-delta-12,14-prostaglandin J2 ] 15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions