Definition: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Other names I2190A; I 2190A; AY 22989; AY 22 989; Wyeth Brand of Sirolimus; Rapamune; I-2190A; AY 22-989; Rapamycin