Definition: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Other names Somatomedin C; IGF-I; Insulin Like Somatomedin Peptide I; Insulin-Like Somatomedin Peptide I; Insulin Like Growth Factor I; IGF-I-SmC; IGF-1
IGF-I-IGFBP-3 complex [ Iplex ] administration increases circulating leptin concentrations in short prepubertal, small for gestational age children, suggesting that IGF-I and/or IGFBP-3 may stimulate leptin secretion by adipose tiss
