Definition: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
coord IM with probably precoord CNS/neopl term + site (IM); for GLIOBLASTOMA WITH SARCOMATOUS COMPONENT see GLIOSARCOMA; for GLIOBLASTOMA, RETINAL see RETINOBLASTOMA
Other names Glioblastoma Multiforme; Giant Cell Glioblastoma; Astrocytoma, Grade IV; Grade IV Astrocytomas; Grade IV Astrocytoma; Glioblastomas, Giant Cell; Glioblastomas; Glioblastoma, Giant Cell; Giant Cell Glioblastomas; Astrocytomas, Grade IV
