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Immunologic Capping

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Definition: An energy dependent process following the crosslinking of B CELL ANTIGEN RECEPTORS by multivalent ligands (bivalent anti-antibodies, LECTINS or ANTIGENS), on the B-cell surface. The crosslinked ligand-antigen receptor complexes collect in patches which flow to and aggregate at one pole of the cell to form a large mass - the cap. The caps may then be endocytosed or shed into the environment.  may appear in the literature as "capping of lymphocytes" or "leukocyte capping"; do not confuse with RECEPTOR CAPPING; DF: IMMUNOL CAPPING   
See Also Receptors, Antigen, B-Cell
Other names Capping, Immunologic; Capping, Immunological; Immunological Capping

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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