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Philadelphia Chromosome

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Definition: An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).     
See Also Oncogene Proteins, Fusion 		Other names Ph1 Chromosome; Ph1 Chromosomes; Ph 1 Chromosomes; Chromosomes, Ph1; Chromosomes, Ph 1; Chromosome, Philadelphia; Chromosome, Ph1; Chromosome, Ph 1; 1 Chromosomes, Ph; 1 Chromosome, Ph; Ph 1 Chromosome

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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