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25-Hydroxyvitamin D3 1-alpha-Hydroxylase

More information in Books or onNLM PubMed
Definition: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).      Other names 1-alpha-Hydroxylase, 25-Hydroxyvitamin D; 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol; 25-Hydroxyvitamin D2 1-hydroxylase; 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase; 25-Hydroxyvitamin D 1-alpha-Hydroxylase; 25-Hydroxyergocalciferol 1-alpha-Hydroxylase; 25-Hydroxycholecalciferol-1-Hydroxylase; Cytochrome P-450 CYP27B1; Calcidiol 1-Monooxygenase; CYP27B1; 25-Hydroxycholecalciferol 1-Hydroxylase; Cytochrome P 450 CYP27B1; Calcidiol 1 Monooxygenase; 25 Hydroxyvitamin D3 1 alpha Hydroxylase; 25 Hydroxyvitamin D2 1 hydroxylase; 25 Hydroxyvitamin D 1 alpha Hydroxylase; 25 Hydroxyergocalciferol 1 alpha Hydroxylase; 25 Hydroxycholecalciferol 1 Hydroxylase; 1-hydroxylase, 25-Hydroxyvitamin D2

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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